https://scholars.lib.ntu.edu.tw/handle/123456789/604399
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, Jih Jung | en |
dc.contributor.author | TZONG-HUEI LEE | en |
dc.contributor.author | Cheng, Ming Jen | en |
dc.date.accessioned | 2022-04-14T23:27:53Z | - |
dc.date.available | 2022-04-14T23:27:53Z | - |
dc.date.issued | 2022-03-01 | en |
dc.identifier.issn | 14203049 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/604399 | - |
dc.description.abstract | Bioassay-guided fractionation of extracts derived from solid cultures of a Herbidospora daliensis originating from Taiwan led to the isolation of five new compounds, for which we propose the name herbidosporadalins A–E (1–5), one isolated for the first time, herbidosporadalin F (6), together with two known compounds (7 & 8). Their structures were elucidated by spectroscopic analyses, including 1D-and 2D-NMR experiments with those of known analogues, and on the basis of HR-EI-MS mass spectrometry, their anti-inflammatory activities were also evaluated. Of these isolates, herbidosporadalin A (1), B (2), F (6) and G (8) showed NO inhibitory activity, with IC50 values of 11.8 ± 0.9, 7.1 ± 2.9, 17.8 ± 1.7, and 13.3 ± 6.5 µM, stronger than the positive control quercetin (IC50 = 36.8 ± 1.3 µM). To the best of our knowledge, this is the first report on 3,4-seco-friedelane metabolites (5, 6 & 8) from the genus Herbidospora. | en |
dc.publisher | MDPI | - |
dc.relation.ispartof | Molecules | en |
dc.subject | anti-inflammatory activities | Herbidospora daliensis | streptosporangiaceae | triterpenoids | en |
dc.title | Secondary Metabolites with Anti-Inflammatory Activities from an Actinobacteria Herbidospora daliensis | en |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/molecules27061887 | en |
dc.identifier.scopus | 2-s2.0-85126967609 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85126967609 | en |
dc.relation.pages | Article number 1887 | - |
dc.relation.journalvolume | 27 | en |
dc.relation.journalissue | 6 | en |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Fisheries Science | - |
crisitem.author.dept | Life Science | - |
crisitem.author.orcid | 0000-0001-8036-7563 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
Appears in Collections: | 漁業科學研究所 |
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