https://scholars.lib.ntu.edu.tw/handle/123456789/604401
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | TZONG-HUEI LEE | en |
dc.contributor.author | Hsieh, Chin Lin | en |
dc.contributor.author | Wu, Ho Cheng | en |
dc.contributor.author | Wang, Shih Wei | en |
dc.contributor.author | ANGELA YU-CHEN LIN | en |
dc.contributor.author | Hsiao, George | en |
dc.contributor.author | Cheng, Ming Jen | en |
dc.contributor.author | Hsieh, Wen Tsong | en |
dc.contributor.author | Kuo, Yueh Hsiung | en |
dc.date.accessioned | 2022-04-14T23:27:53Z | - |
dc.date.available | 2022-04-14T23:27:53Z | - |
dc.date.issued | 2021-01-01 | en |
dc.identifier.issn | 10219498 | en |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/604401 | - |
dc.description.abstract | Eight new diterpenes, 6a,7b-dihydroxyferruginol (1), 6a,7a-dihydroxyferruginol (2), 6a-hydroxyhinokiol (3), 4a-hydroxy-7-oxo-18-norabieta-8,11,13-trien-4a-ol (4a), 15,16-dehydrosugiol (5), 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol (6), 7a-acetoxyabieta-8,12-diene-11,14-dione (7), 7a-butyloxyethyloxyabieta-8,12-diene-11,14-dione (8), along withfour known compounds, 6,7-dehydroferruginol (9), 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (10), 7a-11-dihydroxy-12-methoxy-8,11,13-abietatriene (11), and 11,14-dihydroxy-8,11,13-abietatrien-7-one (12) were successfully isolatedfrom the bark of Calocedrus macrolepis var. formosana. The structures of all isolates were elucidated by physical data(appearance, UV, IR, optical rotation) and spectroscopic data (1D, 2D NMR, and HREIMS). Compounds 9, 10, 11, and 12 showed promising growth-inhibitory effect on human lymphatic endothelial cells (LECs). Among these compounds, compound 10 exerted the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs. In conclusion, the results revealed the anti-lymphangiogenic potentials of Formosan C. macrolepis var. formosana. | en |
dc.publisher | Taiwan Food and Drug Administration | - |
dc.relation.ispartof | Journal of Food and Drug Analysis | en |
dc.subject | Anti-lymphangiogenesis | Calocedrus macrolepis var.formosana | Diterpenes | en |
dc.title | Anti-lymphangiogenic diterpenes from the bark of Calocedrus macrolepis var. formosana | en |
dc.type | journal article | en |
dc.identifier.doi | 10.38212/2224-6614.3375 | en |
dc.identifier.scopus | 2-s2.0-85126056476 | en |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85126056476 | en |
dc.relation.pages | 606-621 | - |
dc.relation.journalvolume | 29 | en |
dc.relation.journalissue | 4 | en |
dc.relation.pageend | 621 | en |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Fisheries Science | - |
crisitem.author.dept | Life Science | - |
crisitem.author.orcid | 0000-0001-8036-7563 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
顯示於: | 漁業科學研究所 |
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