https://scholars.lib.ntu.edu.tw/handle/123456789/604865
標題: | The association of anemia with the clinical outcomes of community-acquired pneumonia in children | 作者: | Chang, I-Fan WEI-LIANG SHIH Liu, Yun-Chung Ho, Te-Wei TING-YU YEN HSIU-HAO CHANG LUAN-YIN CHANG CHI-TAI FANG FEI-PEI LAI |
關鍵字: | anemia; child; empyema; outcome; pneumonia | 公開日期: | 2022 | 出版社: | John Wiley and Sons Inc | 卷: | 57 | 期: | 6 | 起(迄)頁: | 1416 - 1424 | 來源出版物: | Pediatric Pulmonology | 摘要: | Objectives: Anemia is associated with severe outcomes in adult community-acquired pneumonia (CAP), but few studies investigated its association with pediatric CAP. Hence, we tried to delineate the association of anemia with the clinical outcomes of CAP in children. Methods: This retrospective cohort study was conducted from 2010 to 2019 in a medical center. Inpatients aged 6 months to 17 years who were diagnosed with CAP and without major underlying diseases were included. The subjects' clinical data within 24 h of admission and clinical outcomes were collected. We accessed the rates of adverse outcomes and the adjusted odds ratios (ORs) of these outcomes between anemic and nonanemic patients, as well as among patients with different types of anemia. Results: In this study of 3601 patients, the prevalence of anemia was 11.6% (418/3601). Anemic patients had higher rates of intensive care (16.8% vs. 3.6%; p < 0.001), endotracheal intubation (11.0% vs. 1.3%; p < 0.001), and empyema (8.6% vs. 0.6%; p < 0.001) than nonanemic patients. In addition, anemia was independently associated with intensive care (adjusted OR, 3.00; 95% confidence interval [CI], 2.03–4.42), endotracheal intubation (adjusted OR, 3.79; 95% CI, 2.17–6.63), and empyema (adjusted OR, 4.72; 95% CI, 2.30–9.69). Iron-deficiency anemia (IDA) and normocytic anemia were associated with these adverse outcomes but not with anemia due to thalassemia trait. Conclusion: Anemia is a biomarker associated with poor outcomes in pediatric CAP, and patients with IDA or normocytic anemia should be carefully monitored and managed since they may have higher disease severity. © 2022 Wiley Periodicals LLC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127012517&doi=10.1002%2fppul.25892&partnerID=40&md5=630a3e08de3a6ccad314ddcdf4eae319 https://scholars.lib.ntu.edu.tw/handle/123456789/604865 |
ISSN: | 8755-6863 | DOI: | 10.1002/ppul.25892 | SDG/關鍵字: | adult; anemia; child; community acquired infection; complication; empyema; human; iron deficiency anemia; pneumonia; retrospective study; Adult; Anemia; Anemia, Iron-Deficiency; Child; Community-Acquired Infections; Empyema; Humans; Pneumonia; Retrospective Studies |
顯示於: | 流行病學與預防醫學研究所 |
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