https://scholars.lib.ntu.edu.tw/handle/123456789/605774
標題: | Long-Term Clinical Outcomes of Fractional Flow Reserve-Guided Coronary Artery Revascularization in Chronic Kidney Disease | 作者: | CHIEN-BOON JONG Lu, Tsui-Shan Liu, Patrick Yan-Tyng JENG-WEI CHEN CHING-CHANG HUANG HSIEN-LI KAO |
關鍵字: | chronic kidney disease; clinical outcome; fractional flow reserve; revascularization | 公開日期: | 1-一月-2022 | 卷: | 12 | 期: | 1 | 來源出版物: | Journal of personalized medicine | 摘要: | Fractional flow reserve (FFR)-guided percutaneous coronary intervention has shown favorable long-term clinical outcomes. However, limited data exist evaluating the FFR assessment among the chronic kidney disease (CKD) population. The aim of this study was to evaluate the long-term clinical outcomes of FFR-guided coronary revascularization in patients with CKD. A total of 242 CKD patients who underwent FFR assessment were retrospectively analyzed. Patients were divided into two groups: revascularization (FFR ≤ 0.80) and non-revascularization (FFR > 0.80). The primary endpoint was the composite of cardiac death, non-fatal myocardial infarction, and target vessel failure (TVF). The key secondary endpoint was TVF. The Cox regression model was used for risk evaluation. With 91% of the ischemic vessels revascularized, the revascularization group had higher risks for both the primary endpoint (adjusted hazard ratio [aHR]: 2.06; 95% confidence interval [CI], 1.07-3.97; p = 0.030) and key secondary endpoint (aHR: 2.19, 95% CI: 1.10-4.37; p = 0.026), during a median follow-up of 2.9 years. This result was consistent among different CKD severities. In patients with CKD, functional ischemia in coronary artery stenosis was associated with poor clinical outcomes despite coronary revascularization. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/605774 | ISSN: | 2075-4426 | DOI: | 10.3390/jpm12010021 |
顯示於: | 醫學系 |
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