https://scholars.lib.ntu.edu.tw/handle/123456789/605778
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu, Yi-Hsieng Samuel | en_US |
dc.contributor.author | Lin, Yi-Ling | en_US |
dc.contributor.author | WEN-YUAN YANG | en_US |
dc.contributor.author | SHENG-YAO WANG | en_US |
dc.contributor.author | YI-CHEN CHEN | en_US |
dc.creator | Wu Y.-H.S;Lin Y.-L;Yang W.-Y;Wang S.-Y;Chen Y.-C. | - |
dc.date.accessioned | 2022-04-25T03:56:33Z | - |
dc.date.available | 2022-04-25T03:56:33Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 10219498 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110287231&doi=10.38212%2f2224-6614.3351&partnerID=40&md5=db1b2a60d5f3cba469d131d9447f19db | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/605778 | - |
dc.description.abstract | This study aims to clarify the effects of chicken liver hydrolysates (CLHs) on long-term high-fat diet (HFD)-induced insulin resistance (IR) and hepatosteatosis in mice. In vitro, the 400 mM oleic acid (OA)-added medium successfully stimulated the cellular steatosis on FL83B cells, and the cellular steatosis was attenuated ( p < 0.05) by supplementing with CLHs (4 mg/L). In vivo, the effects of CLHs on IR and hepatosteatosis development were tested in 20-week HFD-fed mice. HFD-induced increases in final body weight, but body weight gains of mice were decreased ( p < 0.05) by supplementing CLHs. Elevated ( p < 0.05) serum aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), free fatty acids (FFAs), triglyceride (TG), total cholesterol (TC), and fasted glucose values in HFD-fed mice decreased ( p < 0.05) by supplementing CLHs. Both results of hepatic steatosis and fibrotic scores also indicated the retardation ( p < 0.05) of the hepatosteatosis in cotreated groups. Moreover, the CLH supplementation sustained ( p < 0.05) hepatic and peripheral insulin signal sensitivity in HFD-fed mice. CLH supplementation could ameliorate hepatic lipid deposition, hepatic/peripheral IR in a long-term high-fat dietary habit, and also improve the universal glucose homeostasis by upregulating hepatic and peripheral insulin sensitivities. ? 2021, Taiwan Food and Drug Administration. All rights reserved. | - |
dc.relation.ispartof | Journal of Food and Drug Analysis | - |
dc.subject | Adipose tissue | - |
dc.subject | Chicken-liver hydrolysates | - |
dc.subject | Insulin resistance | - |
dc.subject | Non-alcoholic fatty liver disease | - |
dc.subject | Skeletal muscle | - |
dc.subject | alanine aminotransferase | - |
dc.subject | albumin | - |
dc.subject | alkaline phosphatase | - |
dc.subject | aspartate aminotransferase | - |
dc.subject | catalase | - |
dc.subject | fatty acid | - |
dc.subject | glucose | - |
dc.subject | glutathione | - |
dc.subject | glutathione peroxidase | - |
dc.subject | insulin | - |
dc.subject | interleukin 1beta | - |
dc.subject | ketone body | - |
dc.subject | liver protective agent | - |
dc.subject | oleic acid | - |
dc.subject | pepsin A | - |
dc.subject | protein hydrolysate | - |
dc.subject | superoxide dismutase | - |
dc.subject | thiobarbituric acid reactive substance | - |
dc.subject | triacylglycerol | - |
dc.subject | tumor necrosis factor | - |
dc.subject | alanine aminotransferase blood level | - |
dc.subject | albumin blood level | - |
dc.subject | alkaline phosphatase blood level | - |
dc.subject | animal cell | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | animal tissue | - |
dc.subject | Article | - |
dc.subject | aspartate aminotransferase blood level | - |
dc.subject | body weight gain | - |
dc.subject | cell degeneration | - |
dc.subject | chicken | - |
dc.subject | cholesterol blood level | - |
dc.subject | controlled study | - |
dc.subject | eating habit | - |
dc.subject | fatty acid blood level | - |
dc.subject | fatty liver | - |
dc.subject | FL83B cell line | - |
dc.subject | glucose blood level | - |
dc.subject | in vitro study | - |
dc.subject | in vivo study | - |
dc.subject | insulin resistance | - |
dc.subject | lipid diet | - |
dc.subject | lipid storage | - |
dc.subject | liver protection | - |
dc.subject | liver tissue | - |
dc.subject | male | - |
dc.subject | mouse | - |
dc.subject | nonhuman | - |
dc.subject | steatosis | - |
dc.subject | stimulation | - |
dc.subject | triacylglycerol blood level | - |
dc.subject | trolox equivalent antioxidant capacity | - |
dc.subject | upregulation | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Pepsin-digested chicken-liver hydrolysate attenuates hepatosteatosis by relieving hepatic and peripheral insulin resistance in long-term high-fat dietary habit | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.38212/2224-6614.3351 | - |
dc.identifier.scopus | 2-s2.0-85110287231 | - |
dc.relation.pages | 375-388 | - |
dc.relation.journalvolume | 29 | - |
dc.relation.journalissue | 2 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Veterinary Medicine | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.dept | Animal Science and Technology | - |
crisitem.author.dept | Master Program in Global Agriculture Technology and Genomic Science (Global ATGS) | - |
crisitem.author.orcid | 0000-0003-2167-6803 | - |
crisitem.author.orcid | 0000-0002-4616-2115 | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | International College | - |
顯示於: | 氣候變遷與永續發展國際學位學程(含碩士班、博士班) |
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