https://scholars.lib.ntu.edu.tw/handle/123456789/605982
標題: | Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis | 作者: | Wang T.-E Minabe S Matsuda F Li S.-H Tsukamura H Maeda K.-I Smith L O?ara L Gadella B.M PEI-SHIUE TSAI |
關鍵字: | glutamic acid;messenger RNA;quiescin sulfhydryl oxidase 2;testosterone;thiol oxidase;unclassified drug;carrier protein;glutamate transporter;glutamine;glutamine transport proteins;oxidoreductase;Qsox2 protein, mouse;animal cell;animal tissue;Article;controlled study;epididymis;hormonal regulation;male;mouse;nonhuman;priority journal;protein expression;protein synthesis;RNA sequencing;signal transduction;spermatozoon maturation;transcriptomics;two dimensional cell culture;animal;cytology;drug effect;gene expression regulation;genetics;Institute for Cancer Research mouse;metabolism;Amino Acid Transport System X-AG;Animals;Carrier Proteins;Epididymis;Gene Expression Regulation;Glutamic Acid;Glutamine;Male;Mice;Mice, Inbred ICR;Oxidoreductases Acting on Sulfur Group Donors;Sperm Maturation;Testosterone | 公開日期: | 2021 | 卷: | 161 | 期: | 5 | 起(迄)頁: | 593-602 | 來源出版物: | Reproduction | 摘要: | The epididymis is an androgen-responsive organ, whose structure and functions are modulated by the coordination between androgen and epididymal cues. Highly regulated molecular interaction within the epididymis is required to support viable sperm development necessary for subsequent fertilization. In the present study, we extended our earlier findings on a promising epididymal protein, quiescin sulfhydryl oxidase 2 (QSOX2), and demonstrated a positive correlation between testosterone and QSOX2 protein synthesis through the use of loss- and restore-of-function animal models. Moreover, based on transcriptomic analyses and 2D culture system, we determined that an additional polarized effect of glutamate is indispensable for the regulatory action of testosterone on QSOX2 synthesis. In conclusion, we propose noncanonical testosterone signaling supports epididymal QSOX2 protein synthesis, providing a novel perspective on the regulation of sperm maturation within the epididymis. ? 2021 Society for Reproduction and Fertility |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105699452&doi=10.1530%2fREP-20-0629&partnerID=40&md5=116b0f10cbbe051da2eca065d180c83f https://scholars.lib.ntu.edu.tw/handle/123456789/605982 |
ISSN: | 14701626 | DOI: | 10.1530/REP-20-0629 |
顯示於: | 獸醫學系 |
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