https://scholars.lib.ntu.edu.tw/handle/123456789/605989
標題: | Article l-asparaginase, doxorubicin, vincristine, and prednisolone (Lhop) chemotherapy as a first-line treatment for dogs with multicentric lymphoma | 作者: | Lee J.-J Liao A.T TAI-CHING LIAO JIH-JONG LEE SHANG-LIN WANG |
關鍵字: | Canine;L-asparaginase;Lymphosarcoma;Oncology;Outcome | 公開日期: | 2021 | 卷: | 11 | 期: | 8 | 來源出版物: | Animals | 摘要: | Cyclophosphamide exhibits the weakest therapeutic effect compared with vincristine and doxorubicin in the CHOP (C, cyclophosphamide; H, doxorubicin; O, vincristine; and P, prednisolone) chemotherapeutic protocol for the treatment of canine lymphoma. Twenty dogs with multicentric lymphoma were treated using the LHOP protocol, which used l-asparaginase in place of cyclophos-phamide, and the outcomes were historically compared with those of dogs that received CHOP chemotherapy in the same institution. No significant differences were found in age (p = 0.107), body weight (p = 0.051), sex (p = 0.453), clinical stage V (p = 1), substage b (p = 0.573), T-cell phenotype (p = 0.340), overall response (p = 1), and hypercalcaemia status (p = 1) between the LHOP and CHOP groups. The adverse effects of l-asparaginase were well tolerated and self-limiting. The median PFS (progression-free survival) and median ST (survival time) in the LHOP group were 344 days (range: 28–940 days) and 344 days (range: 70–940 days), respectively. The median PFS and median ST in the CHOP group were 234 days (range: 49–1822 days) and 314 days (range: 50–1822 days), respectively. The dogs that received LHOP chemotherapy had a significantly longer PFS than the dogs that received CHOP chemotherapy (p = 0.001). No significant difference was observed in ST between the LHOP and CHOP groups (p = 0.131). Our study findings thus indicate that the LHOP protocol can be used as a first-line chemotherapeutic protocol in canine multicentric lymphoma. ? 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111021129&doi=10.3390%2fani11082199&partnerID=40&md5=9652ac7f5c635d03cb7e8d8ffee926db https://scholars.lib.ntu.edu.tw/handle/123456789/605989 |
ISSN: | 20762615 | DOI: | 10.3390/ani11082199 |
顯示於: | 獸醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。