https://scholars.lib.ntu.edu.tw/handle/123456789/606111
標題: | Deformed wing virus infection affects the neurological function of Apis mellifera by altering extracellular adenosine signaling | 作者: | Chen P Lu Y.-H Lin Y.-H Wu C.-P Tang C.-K Wei S.-C YUEH-LUNG WU |
關鍵字: | Adenosine;Deformed wing virus (DWV);Honeybee (Apis mellifera);Long-term memory;adenosine;animal;bee;energy metabolism;memory;metabolism;physiology;RNA virus;signal transduction;virology;Animals;Bees;Energy Metabolism;Memory;RNA Viruses;Signal Transduction | 公開日期: | 2021 | 卷: | 139 | 來源出版物: | Insect Biochemistry and Molecular Biology | 摘要: | Deformed wing virus (DWV) infection is believed to be closely associated with colony losses of honeybee (Apis mellifera) due to reduced learning and memory of infected bees. The adenosine (Ado) pathway is important for maintaining immunity and memory function in animals, and it enhances antivirus responses by regulating carbohydrate metabolism in insects. Nevertheless, its effect on the memory of invertebrates is not yet clear. This study investigated how the Ado pathway regulates energy metabolism and memory in honeybees following DWV infection. Decreased Ado receptor (Ado-R) expression in the brain of infected bees resulted in a carbohydrate imbalance as well as impairments of glutamate-glutamine (Glu-Gln) cycle and long-term memory. Dietary supplementation with Ado not only increased the brain energy metabolism but also rescued long-term memory loss by upregulating the expression of memory-related genes. The present study demonstrated the regulation of the Ado pathway upon DWV infection and provides insights into the mechanisms underlying energy regulation and the neurological function of honeybees. ? 2021 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118500573&doi=10.1016%2fj.ibmb.2021.103674&partnerID=40&md5=d97e3c389fbb17bbaaf565bfe7a87a0d https://scholars.lib.ntu.edu.tw/handle/123456789/606111 |
ISSN: | 09651748 | DOI: | 10.1016/j.ibmb.2021.103674 |
顯示於: | 昆蟲學系 |
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