https://scholars.lib.ntu.edu.tw/handle/123456789/608806
標題: | Differential effects of saturated fatty acids on the risk of metabolic syndrome: a matched case-control and meta-analysis study | 作者: | Wei-Sin Yang Pei-Chun Chen Hsiu-Ching Hsu TA-CHEN SU HUNG-JU LIN MING-FONG CHEN Yuan-Teh Lee KUO-LIONG CHIEN |
關鍵字: | Meta-analysis; Metabolic syndrome; Saturated fatty acids | 公開日期: | 一月-2018 | 出版社: | W.B. Saunders | 卷: | 83 | 起(迄)頁: | 42-49 | 來源出版物: | Metabolism: Clinical and Experimental | 摘要: | Background: We investigated the association between plasma saturated fatty acids (SFAs) and the risk of metabolic syndrome among ethnic Chinese adults in Taiwan who attended a health check-up center. Methods: A case-control study based on 1000 cases of metabolic syndrome and 1:1 matched control participants (mean age, 54.9 ± 10.7 y; 36% females) were recruited. Metabolic syndrome was defined according to the criteria of the International Diabetes Federation. Gas chromatography was used to measure the distribution of fatty acids in plasma (% of total fatty acids). Results: Even-chain SFAs, including 14:0, 16:0, and 18:0, were associated with metabolic syndrome; the adjusted odds ratio [OR] and 95% confidence interval [CI] per standard deviation [SD] difference was 3.32, [1.98-5.59]; however, very-long-chain SFAs, including 20:0, 21:0, 22:0, 23:0, and 24:0, were inversely associated with metabolic syndrome. The adjusted OR [95% CI] per SD difference was 0.67 [0.58-0.78]. The area under the receiver operative characteristic curve increased from 0.814 in the basic model to 0.815 (p = 0.54, compared with the basic model), 0.818 (p < 0.0001), and 0.820 (p < 0.0001) after adding odd-chain, even-chain, and very-long chain SFAs. A meta-analysis based on 12 studies showed that the summarized OR for type 2 diabetes mellitus was 1.16 [0.96-1.41] for the top versus bottom SFAs. Conclusions: Different carbon numbers of SFAs have been shown to have differential effects on the status of metabolic syndrome, implying that SFAs are not homogenous for the effects. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042457190&doi=10.1016%2fj.metabol.2018.01.006&partnerID=40&md5=1b6dc646f5fdae0fe2dd6259b024c261 https://scholars.lib.ntu.edu.tw/handle/123456789/608806 https://pubmed.ncbi.nlm.nih.gov/29410352/ |
ISSN: | 0026-0495 | DOI: | 10.1016/j.metabol.2018.01.006 |
顯示於: | 流行病學與預防醫學研究所 |
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