https://scholars.lib.ntu.edu.tw/handle/123456789/609101
Title: | Association of depression and antidepressant therapy with antiretroviral therapy adherence and health-related quality of life in men who have sex with men | Authors: | Yen, Yung-Feng Lai, Hsin-Hao Kuo, Yen-Chun Chan, Shang-Yih LIAN-YU CHEN Chen, Chu-Chieh Wang, Teng-Ho Wang, Chien Chun Chen, Marcelo Yen, Tsen-Fang Kuo, Li-Lan Kuo, Shu-Ting Chuang, Pei-Hung |
Issue Date: | 2022 | Publisher: | Public Library of Science | Journal Volume: | 17 | Journal Issue: | 2 | Source: | PloS one | Abstract: | UNAIDS' HIV treatment targets require that 90% of people living with HIV/AIDS (PLWHA) receiving antiretroviral treatment (ART) achieve viral suppression and 90% of people with viral suppression have good health-related quality of life (HRQOL). This study aimed to examine the association of depression and antidepressant therapy with ART adherence and HRQOL in HIV-infected men who have sex with men (MSM). From 2018 through 2020, HIV-infected MSMs were consecutively recruited (N = 565) for the evaluation of ART adherence and HRQOL at Taipei City Hospital HIV clinics. Non-adherence to ART was defined as a Medication Adherence Report Scale score of < 23. HRQOL in PLWHHA was evaluated using WHOQOL-BREF, Taiwan version. Overall, 14.0% had depression and 12.4% exhibited non-adherence to ART. The nonadherence proportion was 21.8% and 10.5% in depressed and nondepressed HIV-infected MSM, respectively. After adjusting for other covariates, depression was associated with a higher risk of nonadherence to ART (adjusted odds ratio = 2.02; 95% confidence interval: 1.02-4.00). Physical, psychological, social, and environmental HRQOL were significantly negatively associated with depression. Considering antidepressant therapy, ART nonadherence was significantly associated with depression without antidepressant therapy but not with antidepressant therapy. The depressed HIV-infected MSM without antidepressant therapy had worse psychological, social, and environmental HRQOL than those with antidepressant therapy. Our study suggests that depression is associated with poor ART adherence and HRQOL, particularly in those without antidepressant therapy. Adequate diagnosis and treatment of depression should be provided for PLWHA to improve their ART adherence and HRQOL. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125310723&doi=10.1371%2fjournal.pone.0264503&partnerID=40&md5=ace60fdef18f9be98ca2733017fbb14c https://scholars.lib.ntu.edu.tw/handle/123456789/609101 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0264503 |
Appears in Collections: | 流行病學與預防醫學研究所 |
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