https://scholars.lib.ntu.edu.tw/handle/123456789/610413
標題: | Severe immune thrombocytopenia following COVID-19 vaccination (Moderna) and immune checkpoint inhibitor: A case report | 作者: | KAH-MENG CHONG CHING-YAO YANG CHIEN-CHIN LIN WAN-CHING LIEN |
關鍵字: | COVID-19; Immune checkpoint inhibitors; Immune thrombocytopenia; Moderna vaccine; mRNA-based vaccine | 公開日期: | 18-三月-2022 | 來源出版物: | The American journal of emergency medicine | 摘要: | Safe and effective prophylactic vaccines are urgently needed to contain the coronavirus disease 2019 (COVID-19) pandemic. However, several vaccination-related adverse effects have been reported. Here, we report a rare case of severe immune thrombocytopenia occurring 3 days after receiving the mRNA-1273 (Moderna) COVID-19 vaccine in an Asian woman with a history of refractory lung adenocarcinoma treated with durvalumab, an immune checkpoint inhibitor. Treatment with platelet transfusion (12 units) and oral prednisolone (1 mg/kg per day) significantly improved her hemoptysis with thrombocytopenia. To the best of our knowledge, this is the first case of ITP following Moderna inoculation among Asians. This study highlights a potential adverse effect of mRNA-based COVID-19 vaccines in cancer patients receiving immune checkpoint inhibitors. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/610413 | ISSN: | 07356757 | DOI: | 10.1016/j.ajem.2022.03.030 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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