|Title:||Aldosterone-producing adenoma-harbouring KCNJ5 mutations is associated with lower prevalence of metabolic disorders and abdominal obesity||Authors:||Chen, Kuan-Ming
TAIPAI Study Group
|Keywords:||adrenalectomy; idiopathic hyperaldosteronism; KCNJ5 mutations; metabolic syndrome; unilateral aldosterone-producing adenoma; SOMATIC MUTATIONS; EXPRESSION; FREQUENT; RECEPTOR||Issue Date:||2021||Publisher:||LIPPINCOTT WILLIAMS & WILKINS||Journal Volume:||39||Journal Issue:||12||Start page/Pages:||2353||Source:||Journal of hypertension||Abstract:||
Aldosterone overproduction and lipid metabolic disturbances between idiopathic hyperaldosteronism (IHA) and unilateral aldosterone-producing adenoma (APA) have been inconsistently linked in patients with primary aldosteronism. Moreover, KCNJ5 mutations are prevalent among APAs and enhance aldosterone synthesis in adrenal cortex. We aimed to investigate the prevalence of metabolic syndrome (MetS) in each primary aldosteronism subtype and observe the role of KCNJ5 mutations among APAs on the distribution of abdominal adipose tissues quantified using computed tomography (CT), including their changes postadrenalectomy.
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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