https://scholars.lib.ntu.edu.tw/handle/123456789/611259
Title: | Computed tomography of the brain in patients with serum prolactin levels over 200 ng/ml | Authors: | YEUN-CHUNG CHANG HON-MAN LIU Huang, K M Wang, T C Hsu, J C |
Issue Date: | Feb-1991 | Journal Volume: | 90 | Journal Issue: | 2 | Source: | Journal of the Formosan Medical Association = Taiwan yi zhi | Abstract: | We reviewed the computed tomographic (CT) findings of the sella turcica in 26 patients with a serum prolactin level of over 200 ng/ml. The interval between the dates of CT examination and checking of the serum prolactin level were within 2 months. There were 24 nonpregnant women with a mean age of 30 years and 2 men with a mean age of 28.5 years. None of them were taking medication known to cause an elevation in serum prolactin levels. Surgery was performed on 8 patients with chromophobe adenomas of the pituitary gland: 6 of them were proven to have prolactin-secreting tumors (prolactinomas) after performing a special stain, and the remaining 2 patients, clinically diagnosed as prolactinomas, showed extremely high serum prolactin levels (3,200 and 2,251 ng/ml, respectively). CT studies showed that the height of the pituitary gland in the coronal sections were more than 7 mm in 15 cases (58%) and more than 10 mm in 13 cases (50%); focal bulging of the diaphragma sellae in 16 cases (62%); erosion of the sellar floor in 20 cases (77%); deviation of the pituitary stalk in 19 cases (73%); and abnormal attenuation or enhancement of the pituitary gland in 18 cases (69%). Three patients (12%) showed no evidence of any abnormal CT finding despite a hyperprolactinemic state of over 200 ng/ml. Six histologically proven cases (23%) of prolactinomas and chromophobe adenomas showed radiologic evidence of cavernous sinus invasion. We conclude that patients with a serum prolactin level higher than 200 ng/ml generally show significant changes in the sella turcica in CT. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/611259 | ISSN: | 0929-6646 |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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