https://scholars.lib.ntu.edu.tw/handle/123456789/611407
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Safwan, Safwan | en_US |
dc.contributor.author | Hsiao, George | en_US |
dc.contributor.author | TZONG-HUEI LEE | en_US |
dc.contributor.author | Lee, Ching-Kuo | en_US |
dc.date.accessioned | 2022-05-23T08:58:03Z | - |
dc.date.available | 2022-05-23T08:58:03Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1817406X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/611407 | - |
dc.description.abstract | Background: Many groups of fungi live as an endophyte in plants. Both published and undiscovered bioactive compounds can be found in endophytic fungi. Various biological activities of bioactive compounds from endophytic fungi had been reported, including anti-inflammatory and anticancerous effects. The chemical investigation of biologically active compounds from endophytic fungi Melaleuca leucadendra Linn. have not yet been stated. Results: One new compound, namely nigaurdiol (1), along with five known compounds, xyloketal K (2), bostrycin (3), deoxybostrycin (4), xylanthraquinone (5), and ergosterol (6), were isolated from the Melaleuca leucadendra Linn. associated fungal strain Nigrospora aurantiaca#TMU062. Their chemical structures were elucidated by spectroscopic data and compared with literature. All isolated compounds were evaluated for inhibitory effect of NO production in LPS-activated microglial BV-2 cells. Conclusions: Compound 6 exhibited considerable inhibitory effect on NO production with IC50 values of 7.2 ± 1.4 µM and the survival rate of the cells was 90.8 ± 6.7% at the concentration of 10 µM. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Science and Business Media Deutschland GmbH | en_US |
dc.relation.ispartof | Botanical Studies | en_US |
dc.subject | Endophytes fungi | en_US |
dc.subject | Melaleuca leucadendra | en_US |
dc.subject | Nigrospora aurantiaca | en_US |
dc.subject | Nitric oxide production | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Bioactive compounds from an endophytic fungi Nigrospora aurantiaca | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1186/s40529-021-00324-7 | - |
dc.relation.journalvolume | 62 | en_US |
dc.relation.journalissue | 1 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Fisheries Science | - |
crisitem.author.dept | Life Science | - |
crisitem.author.orcid | 0000-0001-8036-7563 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
顯示於: | 漁業科學研究所 |
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