https://scholars.lib.ntu.edu.tw/handle/123456789/611407
標題: | Bioactive compounds from an endophytic fungi Nigrospora aurantiaca | 作者: | Safwan, Safwan Hsiao, George TZONG-HUEI LEE Lee, Ching-Kuo |
關鍵字: | Endophytes fungi;Melaleuca leucadendra;Nigrospora aurantiaca;Nitric oxide production | 公開日期: | 十二月-2021 | 出版社: | Springer Science and Business Media Deutschland GmbH | 卷: | 62 | 期: | 1 | 來源出版物: | Botanical Studies | 摘要: | Background: Many groups of fungi live as an endophyte in plants. Both published and undiscovered bioactive compounds can be found in endophytic fungi. Various biological activities of bioactive compounds from endophytic fungi had been reported, including anti-inflammatory and anticancerous effects. The chemical investigation of biologically active compounds from endophytic fungi Melaleuca leucadendra Linn. have not yet been stated. Results: One new compound, namely nigaurdiol (1), along with five known compounds, xyloketal K (2), bostrycin (3), deoxybostrycin (4), xylanthraquinone (5), and ergosterol (6), were isolated from the Melaleuca leucadendra Linn. associated fungal strain Nigrospora aurantiaca#TMU062. Their chemical structures were elucidated by spectroscopic data and compared with literature. All isolated compounds were evaluated for inhibitory effect of NO production in LPS-activated microglial BV-2 cells. Conclusions: Compound 6 exhibited considerable inhibitory effect on NO production with IC50 values of 7.2 ± 1.4 µM and the survival rate of the cells was 90.8 ± 6.7% at the concentration of 10 µM. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/611407 | ISSN: | 1817406X | DOI: | 10.1186/s40529-021-00324-7 |
顯示於: | 漁業科學研究所 |
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