https://scholars.lib.ntu.edu.tw/handle/123456789/611721
標題: | A tidal lung simulation to quantify lung heterogeneity with the Inspired Sinewave Test | 作者: | Tran M.C. Crockett D.C. Phan P.A. Payne S.J. Farmery A.D. STEPHEN JOHN PAYNE |
關鍵字: | Diseases;Mammals;Random errors;Sensitivity analysis;Testing;Control groups;Expiratory flows;Highly accurate;Lung function;Morris method;Pulmonary embolism;Sine wave test;Tidal volume;Biological organs;animal;human;lung;lung function test;pig;tidal volume;Animals;Humans;Lung;Respiratory Function Tests;Swine;Tidal Volume | 公開日期: | 2020 | 卷: | 2020-July | 起(迄)頁: | 2438-2441 | 來源出版物: | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS | 摘要: | We have created a lung simulation to quantify lung heterogeneity from the results of the inspired sinewave test (IST). The IST is a lung function test that is non-invasive, non-ionising and does not require patients' cooperation. A tidal lung simulation is developed to assess this test and also a method is proposed to calculate lung heterogeneity from IST results. A sensitivity analysis based on the Morris method and linear regression were applied to verify and to validate the simulation. Additionally, simulated emphysema and pulmonary embolism conditions were created using the simulation to assess the ability of the IST to identify these conditions. Experimental data from five pigs (pre-injured vs injured) were used for validation. This paper contributes to the development of the IST. Firstly, our sensitivity analysis reveals that the IST is highly accurate with an underestimation of about 5% of the simulated values. Sensitivity analysis suggested that both instability in tidal volume and extreme expiratory flow coefficients during the test cause random errors in the IST results. Secondly, the ratios of IST results obtained at two tracer gas oscillation frequencies can identify lung heterogeneity (ELV60/ELV180 and Qp60/Qp180). There was dissimilarity between simulated emphysema and pulmonary embolism (p < 0.0001). In the animal model, the control group had ELV60/ELV180 = 0.58 compared with 0.39 in injured animals (p < 0.0001). ? 2020 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091005304&doi=10.1109%2fEMBC44109.2020.9176375&partnerID=40&md5=95f40120cc0648736b39d35b69538df9 https://scholars.lib.ntu.edu.tw/handle/123456789/611721 |
DOI: | 10.1109/EMBC44109.2020.9176375 |
顯示於: | 應用力學研究所 |
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