https://scholars.lib.ntu.edu.tw/handle/123456789/611748
標題: | Autoregulating cerebral tissue selfishly exploits collateral flow routes through the circle of willis | 作者: | Kennedy McConnell F.A. Payne S.J. STEPHEN JOHN PAYNE |
關鍵字: | autoregulation;brain blood flow;brain blood vessel;brain circulus arteriosus;brain ischemia;brain tissue;capillary resistance;collateral circulation;hemisphere;internal carotid artery;internal carotid artery occlusion;negative feedback;tissue survival;vascular resistance;anatomical variation;anatomy and histology;biological model;brain circulation;brain infarction;carotid artery disease;cerebrovascular accident;cerebrovascular disease;homeostasis;human;pathophysiology;physiology;Anatomic Variation;Brain Infarction;Carotid Artery Diseases;Carotid Artery, Internal;Cerebrovascular Circulation;Cerebrovascular Disorders;Circle of Willis;Collateral Circulation;Homeostasis;Humans;Models, Cardiovascular;Stroke | 公開日期: | 2018 | 卷: | 126 | 起(迄)頁: | 275-279 | 來源出版物: | Acta Neurochirurgica, Supplementum | 摘要: | Objective: Ischemic stroke is a leading cause of death and disability. Autoregulation and collateral blood flow through the circle of Willis both play a role in preventing tissue infarction. A steady-state model of the cerebral arterial network was used to investigate the interaction of these mechanisms when autoregulation is impaired ipsilateral to an occluded artery. Materials and methods: Twelve structural variants of the circle of Willis were modelled with left internal carotid artery occlusion and coupled with (1) a passive model of the cerebral vascular bed, (2) a steady-state model of an autoregulating cerebral vascular bed, and (3) a model in which the contralateral hemisphere autoregulates and the ipsilateral hemisphere does not. Results: Results showed that if the autoregulatory response is impaired ipsilaterally, then, in the autoregulating hemisphere, cerebral flows are preserved at the expense of those on the ipsilateral side. Conclusions: Thus, although autoregulation is an essential facilitator of collateral flow through the circle of Willis, contralateral autoregulation can exacerbate flow reductions if not balanced by the same response in the vascular beds on the ipsilateral side. The status of the autoregulatory response in both hemispheres can strongly influence cerebral blood flows and tissue survival and should, therefore, be monitored in stroke. ? Springer International Publishing AG 2018. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042937127&doi=10.1007%2f978-3-319-65798-1_54&partnerID=40&md5=9743d1bc37511fa5a644d8c0ce48239f https://scholars.lib.ntu.edu.tw/handle/123456789/611748 |
DOI: | 10.1007/978-3-319-65798-1_54 |
顯示於: | 應用力學研究所 |
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