https://scholars.lib.ntu.edu.tw/handle/123456789/611752
標題: | Increased blood pressure variability upon standing up improves reproducibility of cerebral autoregulation indices | 作者: | Mahdi A. Nikolic D. Birch A.A. Olufsen M.S. Panerai R.B. Simpson D.M. Payne S.J. STEPHEN JOHN PAYNE |
關鍵字: | Blood pressure;Flow velocity;Hemodynamics;Tissue;Transient analysis;Arterial blood pressure;Blood pressure variability;Cerebral autoregulation;Cerebral blood flow;Cerebral blood flow velocities;Data collection protocols;Reproducibilities;Variability;Blood vessels;adult;aged;Article;autoregressive with exogenous input;autoregulation index;blood flow velocity;blood pressure measurement;blood pressure variability;brain blood flow;cohort analysis;controlled study;correlation coefficient;diastolic blood pressure;elevated blood pressure;finite impulse response;hemodynamic parameters;human;human experiment;mean arterial pressure;middle cerebral artery;normal human;priority journal;reproducibility;sitting;standing;systolic blood pressure;young adult;blood pressure;body position;brain circulation;female;homeostasis;male;patient positioning;physiology;procedures;sensitivity and specificity;Adult;Aged;Blood Flow Velocity;Blood Pressure;Blood Pressure Determination;Cerebrovascular Circulation;Female;Homeostasis;Humans;Male;Patient Positioning;Posture;Reproducibility of Results;Sensitivity and Specificity | 公開日期: | 2017 | 卷: | 47 | 起(迄)頁: | 151-158 | 來源出版物: | Medical Engineering and Physics | 摘要: | Dynamic cerebral autoregulation, that is the transient response of cerebral blood flow to changes in arterial blood pressure, is currently assessed using a variety of different time series methods and data collection protocols. In the continuing absence of a gold standard for the study of cerebral autoregulation it is unclear to what extent does the assessment depend on the choice of a computational method and protocol. We use continuous measurements of blood pressure and cerebral blood flow velocity in the middle cerebral artery from the cohorts of 18 normotensive subjects performing sit-to-stand manoeuvre. We estimate cerebral autoregulation using a wide variety of black-box approaches (including the following six autoregulation indices ARI, Mx, Sx, Dx, FIR and ARX) and compare them in the context of reproducibility and variability. For all autoregulation indices, considered here, the intra-class correlation was greater during the standing protocol, however, it was significantly greater (Fisher's Z-test) for Mx (p < 0.03), Sx (p < 0.003) and Dx (p < 0.03). In the specific case of the sit-to-stand manoeuvre, measurements taken immediately after standing up greatly improve the reproducibility of the autoregulation coefficients. This is generally coupled with an increase of the within-group spread of the estimates. ? 2017 IPEM |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021664854&doi=10.1016%2fj.medengphy.2017.06.006&partnerID=40&md5=d30bc6876c7d5b4ca056066c0da34656 https://scholars.lib.ntu.edu.tw/handle/123456789/611752 |
DOI: | 10.1016/j.medengphy.2017.06.006 |
顯示於: | 應用力學研究所 |
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