https://scholars.lib.ntu.edu.tw/handle/123456789/611778
標題: | Identifying the ischaemic penumbra using pH-weighted magnetic resonance imaging | 作者: | Harston G.W.J. Tee Y.K. Blockley N. Okell T.W. Thandeswaran S. Shaya G. Sheerin F. Cellerini M. Payne S. Jezzard P. Chappell M. Kennedy J. STEPHEN JOHN PAYNE |
關鍵字: | antifibrinolytic agent;adult;aged;amide proton transfer ratio analysis;analytic method;Article;brain blood flow;brain ischemia;brain region;cell pH;clinical article;cohort analysis;disease severity;echo planar imaging;female;fibrinolysis;human;male;middle aged;neuroimaging;nuclear magnetic resonance imaging;nuclear magnetic resonance scanner;priority journal;prospective study;tissue perfusion;analysis of variance;brain circulation;brain infarction;complication;diffusion weighted imaging;image processing;physiology;Stroke;very elderly;Aged, 80 and over;Analysis of Variance;Brain Infarction;Brain Ischemia;Cerebrovascular Circulation;Cohort Studies;Diffusion Magnetic Resonance Imaging;Female;Humans;Image Processing, Computer-Assisted;Male;Middle Aged | 公開日期: | 2015 | 卷: | 138 | 期: | 1 | 起(迄)頁: | 36-42 | 來源出版物: | Brain | 摘要: | The original concept of the ischaemic penumbra suggested imaging of regional cerebral blood flow and metabolism would be required to identify tissue that may benefit from intervention. Amide proton transfer magnetic resonance imaging, a chemical exchange saturation transfer technique, has been used to derive cerebral intracellular pH in preclinical stroke models and has been proposed as a metabolic marker of ischaemic penumbra. In this proof of principle clinical study, we explored the potential of this pH-weighted magnetic resonance imaging technique at tissue-level. Detailed voxel-wise analysis was performed on data from a prospective cohort of 12 patients with acute ischaemic stroke. Voxels within ischaemic core had a more severe intracellular acidosis than hypoperfused tissue recruited to the final infarct (P < 0.0001), which in turn was more acidotic than hypoperfused tissue that survived (P < 0.0001). In addition, when confined to the grey matter perfusion deficit, intracellular pH (P < 0.0001), but not cerebral blood flow (P = 0.31), differed between tissue that infarcted and tissue that survived. Within the presenting apparent diffusion coefficient lesion, intracellular pH differed between tissue with early apparent diffusion lesion pseudonormalization and tissue with true radiographic recovery. These findings support the need for further investigation of pH-weighted imaging in patients with acute ischaemic stroke. ? 2014 The Author. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928181979&doi=10.1093%2fbrain%2fawu374&partnerID=40&md5=5142a8d59df70213e048cdcbcd25e221 https://scholars.lib.ntu.edu.tw/handle/123456789/611778 |
ISSN: | 00068950 | DOI: | 10.1093/brain/awu374 |
顯示於: | 應用力學研究所 |
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