https://scholars.lib.ntu.edu.tw/handle/123456789/611835
標題: | Wavelet phase synchronization analysis of cerebral blood flow autoregulation | 作者: | Peng T. Rowley A.B. Ainslie P.N. Poulin M.J. Payne S.J. STEPHEN JOHN PAYNE |
關鍵字: | Blood;Blood pressure;Frequency bands;Hemodynamics;Physiological models;Synchronization;Tissue;Autoregulations;Cerebral autoregulation;Cerebral blood flow;Cerebral blood flow velocities;Cerebral hemodynamics;Experimental data;Frequency regions;Linear transfer function;Low frequency band;Low frequency range;Low-coherence;Mean arterial blood pressures;Multiple inputs;Nonstationary;Phase difference;Phase distortions;Phase dynamics;Phase synchronization;Stationarity;Synchronization index;Transfer functions;arterial pressure;article;autoregulation;blood flow velocity;brain blood flow;frequency modulation;algorithm;blood pressure;brain circulation;brain cortex;computer simulation;electroencephalography;homeostasis;human;multivariate analysis;physiology;procedures;signal processing;vascularization;carbon dioxide;Algorithms;Blood Flow Velocity;Blood Pressure;Carbon Dioxide;Cerebral Cortex;Cerebrovascular Circulation;Computer Simulation;Electroencephalography;Homeostasis;Humans;Multivariate Analysis;Signal Processing, Computer-Assisted | 公開日期: | 2010 | 卷: | 57 | 期: | 4 | 起(迄)頁: | 960-968 | 來源出版物: | IEEE Transactions on Biomedical Engineering | 摘要: | The dynamic relationship between beat-to-beat mean arterial blood pressure (ABP) fluctuations and cerebral blood flow velocity (CBFV) variations have been intensively studied. The experimentally observed low coherence in the low-frequency band has previously indicated that the assumptions of linearity and/or stationarity, the preconditions of the linear transfer function analysis, are not valid in that frequency region. Latka et al. [M. Latka, M. Turalska, M. Glaubic-Latka, W. Kolodziej, D. Latka, and B. J. J. West, "Phase dynamics in cerebral autoregulation", Amer. J. Physiol. Heart Circ. Physiol., vol. 289 pp. H2272H2279, Jul. 2005] used a wavelet phase synchronization method to identify the instantaneous phase difference between ABP and CBFV, and low values of synchronization index were found in the low-frequency range, seeming to provide further evidence that the cerebral autoregulation system is nonstationary. Here, we focus on another possible factor corresponding for this low synchronization index-unmeasured variability. We demonstrate analytically and with a physiologically based cerebral hemodynamic model that, in the case of multiple inputs, the phase difference between one input, ABP, and the output, CBFV, will be distorted by an additional input, end-tidal CO2 ( PETCO2), and no longer accurately represent the true ABPCBFV system phase shift. We also prove that this phase distortion can be corrected if the transfer functions for ABP-CBFV and PETCO2-CBFV are known or can be estimated. A significantly increased value of synchronization index in the low-frequency band is found by using the CO2 correction term with experimental data on 13 subjects. This essentially indicates that the lack of synchronization between ABP and CBFV previously identified by Latka et al. [M. Latka, M. Turalska, M. Glaubic-Latka, W. Kolodziej, D. Latka, and B. J. J. West, "Phase dynamics in cerebral autoregulation", Amer. J. Physiol. Heart Circ. Physiol., vol.289, pp. H2272H2279, Jul. 2005] can be partly attributed to unmeasured variability. ? 2010 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77950199851&doi=10.1109%2fTBME.2009.2024265&partnerID=40&md5=c0122326a074b83ed711ed3300508d20 https://scholars.lib.ntu.edu.tw/handle/123456789/611835 |
DOI: | 10.1109/TBME.2009.2024265 |
顯示於: | 應用力學研究所 |
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