https://scholars.lib.ntu.edu.tw/handle/123456789/611842
標題: | A three-state non-linear model of vascular nitric oxide transport | 作者: | Abatay H. Payne S.J. STEPHEN JOHN PAYNE |
關鍵字: | Blood vessels;Feedback;Nitric oxide;Autoregulations;Biological experiments;Blood vessel walls;Detailed modeling;Feedback mechanisms;No productions;Non-linear model;Oscillation frequency;Oscillating flow | 公開日期: | 2009 | 起(迄)頁: | 4917-4920 | 來源出版物: | Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 | 摘要: | Nitric Oxide (NO) plays a crucial role in the regulation of blood flow around the body. Biological experiments have shown that blocking NO production induces vasomotion, which is caused by instabilities in blood vessel walls. It has been suggested that the observed vasomotion on NO blockade is because a NO flow dependent system is actually stabilised by the myogenic system, since the coupling together of two unstable mechanisms can enable a system to become stable. We thus propose here a model for the interaction between flow and NO production, with a flow feedback mechanism and analyse its stability both numerically and analytically. We show that the presence of flow feedback introduces instability, which thus provides the basis for a more detailed model of the autoregulation response, when coupled with a model of the myogenic response, and derive a result for the oscillation frequency of the system. ?2009 IEEE. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77951015858&doi=10.1109%2fIEMBS.2009.5332467&partnerID=40&md5=9e3f5026c36bb3648c62dd85feb502f1 https://scholars.lib.ntu.edu.tw/handle/123456789/611842 |
DOI: | 10.1109/IEMBS.2009.5332467 |
顯示於: | 應用力學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。