https://scholars.lib.ntu.edu.tw/handle/123456789/612063
Title: | Anticytokine autoantibodies: Autoimmunity trespassing on antimicrobial immunity | Authors: | ARISTINE CHENG Holland, Steven M |
Keywords: | Anticytokine autoantibodies; adult-onset immunodeficiency; anti-IFN-alpha; anti–CM-CSF; anti–IFN-γ; anti–IL-12; anti–IL-17; anti–IL-23; chronic mucocutaneous candidiasis; opportunistic infections; protein alveolar proteinosis | Issue Date: | 2022 | Publisher: | MOSBY-ELSEVIER | Journal Volume: | 149 | Journal Issue: | 1 | Start page/Pages: | 24 | Source: | The Journal of allergy and clinical immunology | Abstract: | Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/612063 | ISSN: | 0091-6749 | DOI: | 10.1016/j.jaci.2021.11.016 |
Appears in Collections: | 醫學系 |
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