https://scholars.lib.ntu.edu.tw/handle/123456789/613025
標題: | Protocol for human placental mesenchymal stem cell therapy in a murine model of intra-abdominal infection of hypervirulent Klebsiella | 作者: | Wang, Li-Tzu Chiu, Sheng-Kang Lee, Wei Siu, L Kristopher Liu, Ko-Jiunn MEN-LUH YEN Yen, B Linju |
關鍵字: | Flow cytometry/mass cytometry; Immunology; Model organisms; Stem cells | 公開日期: | 2021 | 卷: | 2 | 期: | 1 | 來源出版物: | STAR protocols | 摘要: | Hypervirulent Klebsiella pneumoniae (hvKP) strains cause extra-pulmonary infections such as intra-abdominal infection (IAI) even in healthy individuals due to its resistance to polymorphonuclear neutrophil (PMN) killing and a high incidence of multidrug resistance. To assess whether human placental mesenchymal stem cell (PMSC) therapy can be an effective treatment option, we established a murine model of hvKP-IAI to evaluate immune cell modulation and bacterial clearance for this highly lethal infection. This protocol can rapidly assess potential therapies for severe bacterial IAIs. For complete details on the use and execution of this protocol, please refer to Wang et al. (2020). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/613025 | ISSN: | 26661667 | DOI: | 10.1016/j.xpro.2021.100337 |
顯示於: | 醫學系 |
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