https://scholars.lib.ntu.edu.tw/handle/123456789/616077
標題: | Dynamic changes in heparin-binding protein as a prognostic biomarker for 30-day mortality in sepsis patients in the intensive care unit | 作者: | Dou, Qing-Li Liu, Jiangping Zhang, Wenwu Wang, Ching-Wei Gu, Yanan Li, Na Hu, Rui Hsu, Wan-Ting Huang, Amy Huaishiuan Tong, Hoi Sin Hsu, Tzu-Chun Hsu, Cheng-An Xu, Jun CHIEN-CHANG LEE |
關鍵字: | SEPTIC SHOCK PATIENTS; ORGAN DYSFUNCTION; TRENDS; PREDICTION | 公開日期: | 24-六月-2022 | 出版社: | NATURE PORTFOLIO | 卷: | 12 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | Heparin-binding protein (HBP) has been shown to be a robust predictor of the progression to organ dysfunction from sepsis, and we hypothesized that dynamic changes in HBP may reflect the severity of sepsis. We therefore aim to investigate the predictive value of baseline HBP, 24-h, and 48-h HBP change for prediction of 30-day mortality in adult patients with sepsis. This is a prospective observational study in an intensive care unit of a tertiary center. Patients aged 20 years or older who met SEPSIS-3 criteria were prospectively enrolled from August 2019 to January 2020. Plasma levels of HBP were measured at admission, 24 h, and 48 h and dynamic changes in HBP were calculated. The Primary endpoint was 30-day mortality. We tested whether the biomarkers could enhance the predictive accuracy of a multivariable predictive model. A total of 206 patients were included in the final analysis. 48-h HBP change (HBPc-48 h) had greater predictive accuracy of area under the curve (AUC: 0.82), followed by baseline HBP (0.79), PCT (0.72), lactate (0.71), and CRP (0.65), and HBPc-24 h (0.62). Incorporation of HBPc-48 h into a clinical prediction model significantly improved the AUC from 0.85 to 0.93. HBPc-48 h may assist clinicians with clinical outcome prediction in critically ill patients with sepsis and can improve the performance of a prediction model including age, SOFA score and Charlson comorbidity index. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/616077 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-022-14827-1 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。