https://scholars.lib.ntu.edu.tw/handle/123456789/616087
標題: | Incidence and predictors of idiopathic pneumonia syndrome in hematopoietic stem cell transplant patients: a nationwide registry study | 作者: | Liu, Michael A CHIEN-CHANG LEE Phung, Quan Dao, Quynh-Lan Tehrani, Babak MING YAO Li, Chi-Cheng Wu, Kang-Hsi Chen, Tsung-Chih Gau, Jyh-Pyng Li, Sin-Syue Wang, Po-Nan Liu, Yi-Chang Wang, Tso-Fu Chiou, Lun-Wei Lee, Ming-Yang Yu, Ming-Sun Wang, Chuan-Cheng Lin, Shih-Chiang Chen, Yeu-Chin Chao, Tsu-Yi Ma, Ming-Chun Chen, Chih-Cheng HSIU-HAO CHANG |
關鍵字: | Hematopoietic stem cell transplant; Idiopathic pneumonia syndrome; Incidence; Predictors | 公開日期: | 15-七月-2022 | 出版社: | SPRINGER JAPAN KK | 來源出版物: | International journal of hematology | 摘要: | Idiopathic pneumonia syndrome (IPS) is a rare but deadly complication of hematopoietic stem cell transplantation (HSCT). This study characterized the incidence and risk factors for IPS after HSCT in Taiwan. Data from January 2009 to February 2019 was collected from the Taiwan Society of BMT national registry. Forty-three (1.1%) of 3924 HSCT patients who developed IPS were identified. Incidence of IPS was lower in patients who received autologous HSCT than patients who received allogeneic HSCT (0.68% vs 1.44%, P = 0.022). Multivariate analysis showed that use of TBI and intravenous busulfan in the conditioning regimen were each independent predictor of IPS after HSCT. In addition, development of IPS was significantly associated with increased risk of death in the first 120 days post-HSCT (HR, 2.09; 95% CI, 1.08 to 4.05, P = 0.029) and 2 years post-HSCT (HR, 1.65; 95% CI, 1.07 to 2.542, P = 0.023), but not beyond 2 years post-HSCT. However, survival outcomes did not differ significantly between patients with IPS who received autologous versus allogeneic HSCT (P = 0.52). In conclusion, despite the relatively low incidence of post-HSCT IPS in Taiwan, mortality remains high. The results of this study will help to identify high-risk patients for early intervention and guide future therapeutic research. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/616087 | ISSN: | 0925-5710 | DOI: | 10.1007/s12185-022-03417-6 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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