https://scholars.lib.ntu.edu.tw/handle/123456789/616188
標題: | Comparative effectiveness of generic nifedipine versus Adalat long-acting nifedipine for hypertension treatment: A multi-institutional cohort study | 作者: | Tung, Ying-Chang Lin, Chia-Pin Hsiao, Fu-Chih Ho, Chien-Te Tzyy-Jer, Hsu Chu, You-Chia WEN-JONE CHEN Chu, Pao-Hsien |
關鍵字: | blood pressure; generic drug; nifedipine; outcome | 公開日期: | 2022 | 出版社: | WILEY | 卷: | 24 | 期: | 5 | 起(迄)頁: | 621 | 來源出版物: | Journal of clinical hypertension (Greenwich, Conn.) | 摘要: | This retrospective multi-institutional database analysis aimed to evaluate the blood-pressure-lowering efficacy and clinical outcomes of a generic versus brand-name nifedipine for hypertension management. A total of 12 693 patients who were prescribed a generic or brand-name nifedipine between January 1, 2011, and December 31, 2018, were identified from the Chang Gung Research Database of Chang Gung Memorial Hospitals, Taiwan. Among them, 2112 (21.4%) were prescribed generic nifedipine. After propensity score matching, both the generic and brand-name groups consisted of 2102 patients. At a mean follow-up of 3 years, the changes in office systolic (p for interaction = .791) and diastolic blood pressure (p for interaction = .689) did not differ significantly between the patients who received the generic and the brand-name nifedipine. There was no significant difference between the two study groups regarding the composite of all-cause mortality, acute myocardial infarction, stroke, coronary revascularization, or hospitalization for heart failure (hazard ratio 0.98, 95% confidence interval 0.85-1.13; p = .774). In conclusion, the generic nifedipine was comparable to its brand-name counterpart regarding office blood pressure reduction and the composite cardiovascular outcome for the treatment of patients with hypertension. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/616188 | ISSN: | 1524-6175 | DOI: | 10.1111/jch.14478 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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