https://scholars.lib.ntu.edu.tw/handle/123456789/620667
標題: | Inducing hair follicle neogenesis with secreted proteins enriched in embryonic skin | 作者: | Fan S.M.-Y. Tsai C.-F. Yen C.-M. MIAO-HSIA LIN Wang W.-H. CHIH-CHIEH CHAN Chen C.-L. Phua K.K.L. SZU-HUA PAN Plikus M.V. SUNG-LIANG YU Chen Y.-J. SUNG-JAN LIN |
公開日期: | 2018 | 出版社: | Elsevier Ltd | 卷: | 167 | 起(迄)頁: | 121-131 | 來源出版物: | Biomaterials | 摘要: | Organ development is a sophisticated process of self-organization. However, despite growing understanding of the developmental mechanisms, little is known about how to reactivate them postnatally for regeneration. We found that treatment of adult non-hair fibroblasts with cell-free extract from embryonic skin conferred upon them the competency to regenerate hair follicles. Proteomics analysis identified three secreted proteins enriched in the embryonic skin, apolipoprotein-A1, galectin-1 and lumican that together were essential and sufficient to induce new hair follicles. These 3 proteins show a stage-specific co-enrichment in the perifolliculogenetic embryonic dermis. Mechanistically, exposure to embryonic skin extract or to the combination of the 3 proteins altered the gene expression to an inductive hair follicle dermal papilla fibroblast-like profile and activated Igf and Wnt signaling, which are crucial for the regeneration process. Therefore, a cocktail of organ-specific extracellular proteins from the embryonic environment can render adult cells competent to re-engage in developmental interactions for organ neogenesis. Identification of factors that recreate the extracellular context of respective developing tissues can become an important strategy to promote regeneration in adult organs. © 2018 Elsevier Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85044122254&doi=10.1016%2fj.biomaterials.2018.03.003&partnerID=40&md5=c0e7ce602985b48f9eeaf7c7a0d00206 https://scholars.lib.ntu.edu.tw/handle/123456789/620667 |
ISSN: | 0142-9612 | DOI: | 10.1016/j.biomaterials.2018.03.003 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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