https://scholars.lib.ntu.edu.tw/handle/123456789/620856
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | FAN-CHI CHANG | en_US |
dc.contributor.author | WEN-CHIH CHIANG | en_US |
dc.contributor.author | Tsai, Ming-Hsuan | en_US |
dc.contributor.author | YU-HSIANG CHOU | en_US |
dc.contributor.author | SZU-YU PAN | en_US |
dc.contributor.author | Chang, Yu-Ting | en_US |
dc.contributor.author | Yeh, Pei-Ying | en_US |
dc.contributor.author | YI-TING CHEN | en_US |
dc.contributor.author | CHIH-KANG CHIANG | en_US |
dc.contributor.author | YUNG-MING CHEN | en_US |
dc.contributor.author | TZONG-SHINN CHU | en_US |
dc.contributor.author | KWAN-DUN WU | en_US |
dc.contributor.author | SHUEI-LIONG LIN | en_US |
dc.date.accessioned | 2022-09-16T08:48:45Z | - |
dc.date.available | 2022-09-16T08:48:45Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1046-6673 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/620856 | - |
dc.description.abstract | The mechanism of vascular calcification in CKD is not understood fully, but may involve collagen deposition in the arterial wall upon osteo/chondrocytic transformation of vascular smooth muscle cells (VSMCs). Increased levels of circulating angiopoietin-2 correlate with markers of CKD progression and angiopoietin-2 regulate inflammatory responses, including intercellular and vascular adhesion and recruitment of VSMCs. Here, we investigate the potential role of angiopoietin-2 in the pathogenesis of arterial stiffness associated with CKD. In a cohort of 416 patients with CKD, the plasma level of angiopoietin-2 correlated independently with the severity of arterial stiffness assessed by pulse wave velocity. In mice subjected to 5/6 subtotal nephrectomy or unilateral ureteral obstruction, plasma levels of angiopoietin-2 also increased. Angiopoietin-2 expression markedly increased in tubular epithelial cells of fibrotic kidneys but decreased in other tissues, including aorta and lung, after 5/6 subtotal nephrectomy. Expression of collagen and profibrotic genes in aortic VSMCs increased in mice after 5/6 subtotal nephrectomy and in mice producing human angiopoietin-2. Angiopoietin-2 stimulated endothelial expression of chemokines and adhesion molecules for monocytes, increased Ly6C(low) macrophages in aorta, and increased the expression of the profibrotic cytokine TGF-β1 in aortic endothelial cells and Ly6C(low) macrophages. Angiopoietin-2 blockade attenuated expression of monocyte chemokines, profibrotic cytokines, and collagen in aorta of mice after 5/6 subtotal nephrectomy. This study identifies angiopoietin-2 as a link between kidney fibrosis and arterial stiffness. Targeting angiopoietin-2 to attenuate inflammation and collagen expression may provide a novel therapy for cardiovascular disease in CKD. | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER SOC NEPHROLOGY | en_US |
dc.relation.ispartof | Journal of the American Society of Nephrology : JASN | en_US |
dc.subject | CHRONIC KIDNEY-DISEASE; SMOOTH-MUSCLE-CELLS; STAGE RENAL-DISEASE; CARDIOVASCULAR-DISEASE; ENDOTHELIAL-CELLS; UNITED-STATES; INFLAMMATION; MORTALITY; TIE2; ATHEROSCLEROSIS | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Angiopoietin-2-induced arterial stiffness in CKD | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1681/ASN.2013050542 | - |
dc.identifier.pmid | 24511140 | - |
dc.identifier.scopus | 2-s2.0-84906097639 | - |
dc.identifier.isi | WOS:000336558100011 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/579268 | - |
dc.relation.pages | 1198 | en_US |
dc.relation.journalvolume | 25 | en_US |
dc.relation.journalissue | 6 | en_US |
dc.relation.pageend | 1209 | en_US |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUHJS | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Toxicology | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Institute of Food Safety and Health | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Geriatrics and Gerontology-NTUH | - |
crisitem.author.dept | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Physiology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.orcid | 0000-0002-1821-1952 | - |
crisitem.author.orcid | 0000-0002-8844-0988 | - |
crisitem.author.orcid | 0000-0001-9273-3153 | - |
crisitem.author.orcid | 0000-0002-8738-9463 | - |
crisitem.author.orcid | 0000-0001-9021-4616 | - |
crisitem.author.orcid | 0000-0002-9241-1258 | - |
crisitem.author.orcid | 0000-0002-5291-2509 | - |
crisitem.author.orcid | 0000-0002-3339-1509 | - |
crisitem.author.orcid | 0000-0002-1041-5571 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Jin-shan Branch | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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