https://scholars.lib.ntu.edu.tw/handle/123456789/620878
標題: | Stem cells and kidney regeneration | 作者: | YU-HSIANG CHOU SZU-YU PAN Yang, Chian-Huei SHUEI-LIONG LIN |
關鍵字: | bioengineered kidney; endothelial progenitor cell; kidney regeneration; renal progenitor cell; stem cell | 公開日期: | 四月-2014 | 出版社: | ELSEVIER TAIWAN | 卷: | 113 | 期: | 4 | 起(迄)頁: | 201 | 來源出版物: | Journal of the Formosan Medical Association = Taiwan yi zhi | 摘要: | Kidney disease is an escalating burden all over the world. In addition to preventing kidney injury, regenerating damaged renal tissue is as important as to retard the progression of chronic kidney disease to end stage renal disease. Although the kidney is a delicate organ and has only limited regenerative capacity compared to the other organs, an increasing understanding of renal development and renal reprogramming has kindled the prospects of regenerative options for kidney disease. Here, we will review the advances in the kidney regeneration including the manipulation of renal tubular cells, fibroblasts, endothelial cells, and macrophages in renal disease. Several types of stem cells, such as bone marrow-derived cells, adipocyte-derived mesenchymal stem cells, embryonic stem cells, and induced pluripotent stem cells are also applied for renal regeneration. Endogenous or lineage reprogrammed renal progenitor cells represent an attractive possibility for differentiation into multiple renal cell types. Angiogenesis can ameliorate hypoxia and renal fibrosis. Based on these studies and knowledge, we hope to innovate more reliable pharmacological or biotechnical methods for kidney regeneration medicine. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/620878 | ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2013.12.001 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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