https://scholars.lib.ntu.edu.tw/handle/123456789/620960
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang C.-Y. | en_US |
dc.contributor.author | SHAU-HUAI FU | en_US |
dc.contributor.author | Wang C.-L. | en_US |
dc.contributor.author | Chen P.-J. | en_US |
dc.contributor.author | FE-LIN LIN WU | en_US |
dc.contributor.author | FEI-YUAN HSIAO | en_US |
dc.date.accessioned | 2022-09-19T03:17:02Z | - |
dc.date.available | 2022-09-19T03:17:02Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0937941X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954384561&doi=10.1007%2fs00198-015-3213-z&partnerID=40&md5=3ccccc9928404f3e507143eff62cc2e2 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/620960 | - |
dc.description.abstract | Summary: This is the first study to investigate the association between the use of selective serotonin reuptake inhibitor (SSRI)/serotonin–norepinephrine reuptake inhibitor (SNRI) and the risk of fractures using a nationwide representative cohort of ethnic Chinese. Current use of SSRI/SNRI and the co-morbidity, especially osteoporosis and history of falling, play an important role in the increased risk of fractures. Introduction: This nested case–control study examines the association between the timing, intensity, and individual components of serotonergic antidepressant (including SSRIs and SNRIs) use and the risk of all-cause fracture. Methods: Using the 2002–2011 Taiwan National Health Insurance Research Database, we identified patients who received at least three prescriptions of antidepressants between January 1st 2002 and December 31st 2010 as our study cohort. In the study cohort, we identify 8250 patients who had first admission for fracture and 33,000 matched controls (1:4, matched by age, sex, and cohort entry date). Multivariate conditional logistic regression was used to estimate the association between the use of serotonergic antidepressants and the risk of fracture. Results: Current users of serotonergic antidepressants were associated with an increased risk of fracture (adjusted odds ratio (aOR) 1.16 [95 % confidence interval 1.07–1.25]). Furthermore, a higher risk of fractures was found in patients with osteoporosis (aOR 3.05 [2.73–3.42]) or a history of falling (aOR 6.13 [3.41–11.0]). The risks of fracture between SSRI and SNRI users were comparable. Conclusion: Current use of SSRI/SNRI is associated with an increased risk of all caused fractures. Additionally, the co-morbidity, especially osteoporosis and a history of falling, plays an important role in the risk of fractures. © 2015, International Osteoporosis Foundation and National Osteoporosis Foundation. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Osteoporosis International | en_US |
dc.title | Serotonergic antidepressant use and the risk of fracture: a population-based nested case–control study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s00198-015-3213-z | - |
dc.identifier.pmid | 26126579 | - |
dc.identifier.scopus | 2-s2.0-84954384561 | - |
dc.relation.pages | 57-63 | en_US |
dc.relation.journalvolume | 27 | en_US |
dc.relation.journalissue | 1 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Orthopedic Surgery-NTUHYL | - |
crisitem.author.dept | Orthopedic Surgery | - |
crisitem.author.dept | Orthopedic Surgery-NTUH | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Pharmacy | - |
crisitem.author.dept | School of Pharmacy | - |
crisitem.author.orcid | 0000-0001-9853-872X | - |
crisitem.author.orcid | 0000-0002-5813-1172 | - |
crisitem.author.orcid | 0000-0003-1660-9120 | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 臨床藥學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。