https://scholars.lib.ntu.edu.tw/handle/123456789/621826
標題: | Influence of scalp block on oncological outcomes of high-grade glioma in adult patients with and without isocitrate dehydrogenase-1 mutation | 作者: | Sung, Chao-Hsien FON-YIH TSUANG CHIH-PENG LIN KUANG-CHENG CHAN WEI-HAN CHOU CHUN-YU WU |
關鍵字: | CENTRAL-NERVOUS-SYSTEM; CANCER RECURRENCE; GLIOBLASTOMA; CELL; ANESTHESIA; SURVIVAL; CATECHOLAMINES; CYTOTOXICITY; PROPOFOL; SURGERY | 公開日期: | 2021 | 出版社: | NATURE PORTFOLIO | 卷: | 11 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | High-grade gliomas are notorious for a high recurrence rate even after curative resection surgery. Studies regarding the influence of scalp block on high-grade gliomas have been inconclusive, possibly because the condition's most important genetic mutation profile, namely the isocitrate dehydrogenase 1 (IDH1) mutation, had not been analyzed. Therefore, we conducted a single-center study including patients with high-grade glioma who underwent tumor resection between January 2014 and December 2019. Kaplan-Meier survival analysis revealed that scalp block was associated with longer progression-free survival (PFS; 15.17 vs. 10.77 months, p = 0.0018), as was the IDH1 mutation (37.37 vs. 10.90 months, p = 0.0149). Multivariate Cox regression analysis revealed that scalp block (hazard ratio: 0.436, 95% confidence interval: 0.236-0.807, p = 0.0082), gross total resection (hazard ratio: 0.405, 95% confidence interval: 0.227-0.721, p = 0.0021), and IDH1 mutation (hazard ratio: 0.304, 95% confidence interval: 0.118-0.784, p = 0.0138) were associated with better PFS. Our results demonstrate that application of scalp block, regardless of IDH1 profile, is an independent factor associated with longer PFS for patients with high-grade glioma. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/621826 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-95851-5 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。