https://scholars.lib.ntu.edu.tw/handle/123456789/623059
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHUN-MING HONG | en_US |
dc.contributor.author | Lin, You-Yu | en_US |
dc.contributor.author | CHUN-JEN LIU | en_US |
dc.contributor.author | Lai, Ya-Yun | en_US |
dc.contributor.author | Shiou-Hwei Yeh | en_US |
dc.contributor.author | HUNG-CHIH YANG | en_US |
dc.contributor.author | JIA-HORNG KAO | en_US |
dc.contributor.author | SHIH-JER HSU | en_US |
dc.contributor.author | Huang, Yi-Hsiang | en_US |
dc.contributor.author | Yang, Sheng-Shun | en_US |
dc.contributor.author | Kuo, Hsing-Tao | en_US |
dc.contributor.author | Cheng, Pin-Nan | en_US |
dc.contributor.author | Yu, Ming-Lung | en_US |
dc.contributor.author | PEI-JER CHEN | en_US |
dc.date.accessioned | 2022-09-28T02:45:05Z | - |
dc.date.available | 2022-09-28T02:45:05Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1999-4915 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/623059 | - |
dc.description.abstract | About 4% of the population in Taiwan are seropositive for anti-HCV Ab and 70% with HCV RNA. To address this high chronic hepatitis C disease load, Taiwan National Health Insurance started reimbursing genotype-specific DAAs in 2017 and pangenotype DAAs in mid-2018. With a 97% SVR12 rate, there were still 2-3% of patients that failed to clear HCV. To understand the causes of DAA failure in Taiwan, we conducted a multi-center, clinical, and virologic study. A total of 147 DAA-failure patients were recruited, and we searched HCV NS3/4A, NS5A and NS5B for known resistance-associated substitutions (RASs) by population sequencing, and conducted whole genome sequencing (WGS) for those without known RASs. A total of 107 patients received genotype-specific DAAs while 40 had pangenotype DAAs. Clinically, the important cause of failure is poor adherence. Virologically, common RASs in genotype-specific DAAs were NS5A-L31, NS5A-Y93, and NS5B-C316, while common RASs in pangenotype DAAs were NS5A-L31, NS5A-A/Q/R30, and NS5A-Y93. Additionally, new amino acid changes were found by WGS. Finally, we identified 12 cases with inconsistent baseline and post-treatment HCV genotypes, which is suggestive of re-infection rather than treatment failure. Our study described the drug resistance profile for DAA failure in Taiwan, showing differences from other countries. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | Viruses | en_US |
dc.subject | Taiwan; chronic hepatitis C; direct-acting antiviral agent; resistance-associated substitution; treatment failure; whole genome sequencing | en_US |
dc.title | Drug Resistance Profile and Clinical Features for Hepatitis C Patients Experiencing DAA Failure in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/v13112294 | - |
dc.identifier.pmid | 34835100 | - |
dc.identifier.scopus | 2-s2.0-85119931653 | - |
dc.identifier.isi | WOS:000792953300028 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/592981 | - |
dc.relation.pages | 2294 | en_US |
dc.relation.journalvolume | 13 | en_US |
dc.relation.journalissue | 11 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Microbiology | - |
crisitem.author.dept | Microbiology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.orcid | 0000-0002-0075-1280 | - |
crisitem.author.orcid | 0000-0002-6202-0993 | - |
crisitem.author.orcid | 0000-0003-4509-180X | - |
crisitem.author.orcid | 0000-0003-3864-9895 | - |
crisitem.author.orcid | 0000-0002-2442-7952 | - |
crisitem.author.orcid | 0000-0001-9399-3889 | - |
crisitem.author.orcid | 0000-0001-8316-3785 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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