https://scholars.lib.ntu.edu.tw/handle/123456789/623446
標題: | Genetic susceptibility to dioxin-like chemicals' induction of cytochrome P4501A2 in the human adult linked to specific AhRR polymorphism | 作者: | Wan-Ting Hung Lambert, George H Huang, Ping-Wei Patterson, Donald G Yue Leon Guo |
關鍵字: | Aryl hydrocarbon receptor; Aryl hydrocarbon receptor repressor; CYP1A2 activity and induction; Single nucleotide polymorphisms; Dioxin-like chemicals; PCBs and PCDFs; ARYL-HYDROCARBON RECEPTOR; POLYCHLORINATED-BIPHENYLS PCBS; NUCLEAR TRANSLOCATOR ARNT; TOXIC EQUIVALENCY FACTORS; PRO185ALA POLYMORPHISM; GENOMIC STRUCTURE; REPRESSOR GENE; LUNG-CANCER; CYP1A1; ENDOMETRIOSIS | 公開日期: | 三月-2013 | 出版社: | PERGAMON-ELSEVIER SCIENCE LTD | 卷: | 90 | 期: | 9 | 起(迄)頁: | 2358 | 來源出版物: | Chemosphere | 摘要: | Dioxin-like chemicals are known to exert their effect by binding to aryl hydrocarbon receptor (AhR), forming complexes with aryl hydrocarbon nuclear translocator (ARNT), and binding to dioxin responsive elements (DREs) in promoter region to regulate the transcription of specific genes. In a previous study of the Yucheng cohort of humans who were exposed to high toxic levels of dioxin-like chemicals (PCDFs and PCBs), we reported marked induction of cytochrome P450 1A2 (CYP1A2) activity and this induction was an excellent biomarker of the exposure and adverse human health effects seen in the Yucheng cohort. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/623446 | ISSN: | 0045-6535 | DOI: | 10.1016/j.chemosphere.2012.10.026 |
顯示於: | 醫學系 |
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