https://scholars.lib.ntu.edu.tw/handle/123456789/624072
標題: | Sexually-transmitted hepatitis C virus reinfections among people living with HIV in Taiwan: the emerging role of genotype 6 | 作者: | Chen, Guan-Jhou Sun, Hsin-Yun Chang, Sui-Yuan Su, Li-Hsin YI-TING CHEN Hsieh, Szu-Min Liu, Wan-Da Sheng, Wang-Huei Huang, Yu-Shan Lin, Kuan-Yin Su, Yi-Ching Liu, Wen-Chun Hung, Chien-Ching Chen, Guan-Jhou HSIN-YUN SUN SUI-YUAN CHANG Su, Li-Hsin SZU-MIN HSIEH Liu, Wan-Da WANG-HUEI SHENG YU-SHAN HUANG KUAN-YIN LIN Su, Yi-Ching Liu, Wen-Chun CHIEN-CHING HUNG |
關鍵字: | Men who have sex with men; condomless receptive anal intercourse; genotype switch; phylogenetic analysis; sexually transmitted disease | 公開日期: | 十二月-2022 | 出版社: | TAYLOR & FRANCIS LTD | 卷: | 11 | 期: | 1 | 起(迄)頁: | 1227 | 來源出版物: | Emerging microbes & infections | 摘要: | Hepatitis C virus (HCV) reinfections after successful treatment with direct-acting antivirals (DAAs) pose a significant challenge to HCV elimination, especially among high-risk people living with HIV (PLWH). In this study, PLWH who had achieved HCV viral clearance with DAAs were included between January 2018 and June 2021. PLWH having acquired HCV infections after 2017 were classified as "recent-infection group," and those before 2017 as "remote-infection group," and the incidences of HCV reinfection were compared between two groups. Clinical and behavioural characteristics were evaluated to identify associated factors with HCV reinfection. A total of 284 PLWH were included: 179 in the recent-infection group and 105 in the remote-infection group. After a median follow-up of 2.32 years (interquartile range [IQR], 0.13-3.94), the overall incidence of HCV reinfection was 5.8 per 100 person-years of follow-up (PYFU). The incidence in the recent-infection group was significantly higher than that in the remote-infection group (9.8 vs. 0.4 per 100 PYFU, p < 0.001). The leading HCV genotypes before DAA treatment were genotypes 2 (31.0%), 1b (26.8%), and 6 (21.8%); however, genotype 6 (58.8%) became predominant upon reinfection. Younger age (adjusted odds ratio [aOR] per 1-year increase, 0.95; 95% CI, 0.90-0.99), condomless receptive anal sex (aOR, 14.5; 95% CI, 2.37-88.8), rimming (aOR, 3.87; 95% CI, 1.14-13.1), and recent syphilis (aOR, 2.73; 95% CI, 1.26-5.91) were linked to HCV reinfections. In conclusion, PLWH acquiring HCV after 2017 had a significantly higher risk for sexually-transmitted HCV reinfections. The predominance of HCV genotype 6 reinfections suggests possible on-going clustered HCV infections among at-risk PLWH. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/624072 | ISSN: | 2222-1751 | DOI: | 10.1080/22221751.2022.2065933 |
顯示於: | 醫學系 |
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