https://scholars.lib.ntu.edu.tw/handle/123456789/624072
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen, Guan-Jhou | en_US |
dc.contributor.author | Sun, Hsin-Yun | en_US |
dc.contributor.author | Chang, Sui-Yuan | en_US |
dc.contributor.author | Su, Li-Hsin | en_US |
dc.contributor.author | YI-TING CHEN | en_US |
dc.contributor.author | Hsieh, Szu-Min | en_US |
dc.contributor.author | Liu, Wan-Da | en_US |
dc.contributor.author | Sheng, Wang-Huei | en_US |
dc.contributor.author | Huang, Yu-Shan | en_US |
dc.contributor.author | Lin, Kuan-Yin | en_US |
dc.contributor.author | Su, Yi-Ching | en_US |
dc.contributor.author | Liu, Wen-Chun | en_US |
dc.contributor.author | Hung, Chien-Ching | en_US |
dc.contributor.author | Chen, Guan-Jhou | en_US |
dc.contributor.author | HSIN-YUN SUN | en_US |
dc.contributor.author | SUI-YUAN CHANG | en_US |
dc.contributor.author | Su, Li-Hsin | en_US |
dc.contributor.author | SZU-MIN HSIEH | en_US |
dc.contributor.author | Liu, Wan-Da | en_US |
dc.contributor.author | WANG-HUEI SHENG | en_US |
dc.contributor.author | YU-SHAN HUANG | en_US |
dc.contributor.author | KUAN-YIN LIN | en_US |
dc.contributor.author | Su, Yi-Ching | en_US |
dc.contributor.author | Liu, Wen-Chun | en_US |
dc.contributor.author | CHIEN-CHING HUNG | en_US |
dc.date.accessioned | 2022-10-28T03:02:21Z | - |
dc.date.available | 2022-10-28T03:02:21Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 2222-1751 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/624072 | - |
dc.description.abstract | Hepatitis C virus (HCV) reinfections after successful treatment with direct-acting antivirals (DAAs) pose a significant challenge to HCV elimination, especially among high-risk people living with HIV (PLWH). In this study, PLWH who had achieved HCV viral clearance with DAAs were included between January 2018 and June 2021. PLWH having acquired HCV infections after 2017 were classified as "recent-infection group," and those before 2017 as "remote-infection group," and the incidences of HCV reinfection were compared between two groups. Clinical and behavioural characteristics were evaluated to identify associated factors with HCV reinfection. A total of 284 PLWH were included: 179 in the recent-infection group and 105 in the remote-infection group. After a median follow-up of 2.32 years (interquartile range [IQR], 0.13-3.94), the overall incidence of HCV reinfection was 5.8 per 100 person-years of follow-up (PYFU). The incidence in the recent-infection group was significantly higher than that in the remote-infection group (9.8 vs. 0.4 per 100 PYFU, p < 0.001). The leading HCV genotypes before DAA treatment were genotypes 2 (31.0%), 1b (26.8%), and 6 (21.8%); however, genotype 6 (58.8%) became predominant upon reinfection. Younger age (adjusted odds ratio [aOR] per 1-year increase, 0.95; 95% CI, 0.90-0.99), condomless receptive anal sex (aOR, 14.5; 95% CI, 2.37-88.8), rimming (aOR, 3.87; 95% CI, 1.14-13.1), and recent syphilis (aOR, 2.73; 95% CI, 1.26-5.91) were linked to HCV reinfections. In conclusion, PLWH acquiring HCV after 2017 had a significantly higher risk for sexually-transmitted HCV reinfections. The predominance of HCV genotype 6 reinfections suggests possible on-going clustered HCV infections among at-risk PLWH. | en_US |
dc.language.iso | en | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.relation.ispartof | Emerging microbes & infections | en_US |
dc.subject | Men who have sex with men; condomless receptive anal intercourse; genotype switch; phylogenetic analysis; sexually transmitted disease | en_US |
dc.title | Sexually-transmitted hepatitis C virus reinfections among people living with HIV in Taiwan: the emerging role of genotype 6 | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1080/22221751.2022.2065933 | - |
dc.identifier.pmid | 35412439 | - |
dc.identifier.scopus | 2-s2.0-85128947369 | - |
dc.identifier.isi | WOS:000788343000001 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/620513 | - |
dc.relation.pages | 1227 | en_US |
dc.relation.journalvolume | 11 | en_US |
dc.relation.journalissue | 1 | en_US |
dc.relation.pageend | 1235 | en_US |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Tropical Medicine and Parasitology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-0074-7721 | - |
crisitem.author.orcid | 0000-0002-6009-6724 | - |
crisitem.author.orcid | 0000-0002-1879-4086 | - |
crisitem.author.orcid | 0000-0002-5605-7853 | - |
crisitem.author.orcid | 0000-0002-9047-5709 | - |
crisitem.author.orcid | 0000-0001-6877-5345 | - |
crisitem.author.orcid | 0000-0001-7345-0836 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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