https://scholars.lib.ntu.edu.tw/handle/123456789/624147
標題: | An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoids | 作者: | Chen, Yu-An Lu, Chen-Yu WEN-FANG CHENG KUAN-TING KUO Yu, Chen-Wei HONG-NERNG HO HSIN-FU CHEN SZU-HUA PAN |
關鍵字: | Cancer-initiating cells (CICs); Induced ovarian cancer-initiating cells (iOCICs); Organoid and drug screening; Ovarian cancer (OC) | 公開日期: | 10-九月-2022 | 出版社: | BMC | 卷: | 22 | 期: | 1 | 來源出版物: | BMC cancer | 摘要: | Ovarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are proposed to be responsible for the aggressiveness of OC. The rarity and difficulty of in vitro long-term cultivation of CICs challenge the development of CIC-targeting therapeutics. Reprogramming cancer cells into induced cancer initiating cell (iCICs) could be an approach to solve these. Several inducible CICs have been acquired by activating the expression of stemness genes in different cancer cells. However, few reports have demonstrated the feasibility in OC. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/624147 | ISSN: | 1471-2407 | DOI: | 10.1186/s12885-022-10042-3 |
顯示於: | 醫學系 |
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