https://scholars.lib.ntu.edu.tw/handle/123456789/624311
標題: | A DNA Damage Response Gene Panel for Different Histologic Types of Epithelial Ovarian Carcinomas and Their Outcomes | 作者: | YING-CHENG CHIANG PO-HAN LIN TZU-PIN LU KUAN-TING KUO YI-JOU TAI HENG-CHENG HSU CHIA-YING WU Lee, Chia-Yi Shen, Hung CHI-AN CHEN WEN-FANG CHENG |
關鍵字: | DNA damage response; clear cell carcinoma; epithelial ovarian cancer; somatic mutation | 公開日期: | 3-十月-2021 | 出版社: | MDPI | 卷: | 9 | 期: | 10 | 來源出版物: | Biomedicines | 摘要: | DNA damage response (DDR) is important for maintaining genomic integrity of the cell. Aberrant DDR pathways lead to accumulation of DNA damage, genomic instability and malignant transformations. Gene mutations have been proven to be associated with epithelial ovarian cancer, and the majority of the literature has focused on BRCA. In this study, we investigated the somatic mutation of DNA damage response genes in epithelial ovarian cancer patients using a multiple-gene panel with next-generation sequencing. In all, 69 serous, 39 endometrioid and 64 clear cell carcinoma patients were enrolled. Serous carcinoma patients (69.6%) had higher percentages of DDR gene mutations compared with patients with endometrioid (33.3%) and clear cell carcinoma (26.6%) (p < 0.001, chi-squared test). The percentages of DDR gene mutations in patients with recurrence (53.9 vs. 32.9% p = 0.006, chi-squared test) or cancer-related death (59.2 vs. 34.4% p = 0.001, chi-squared test) were higher than those without recurrence or living patients. In endometrioid carcinoma, patients with ≥2 DDR gene mutations had shorter PFS (p = 0.0035, log-rank test) and OS (p = 0.015, log-rank test) than those with one mutation or none. In clear cell carcinoma, patients with ≥2 DDR gene mutations had significantly shorter PFS (p = 0.0056, log-rank test) and OS (p = 0.0046, log-rank test) than those with 1 DDR mutation or none. In the EOC patients, somatic DDR gene mutations were associated with advanced-stage tumor recurrence and tumor-related death. Type I EOC patients with DDR mutations had an unfavorable prognosis, especially for clear cell carcinoma. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/624311 | ISSN: | 2227-9059 | DOI: | 10.3390/biomedicines9101384 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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