https://scholars.lib.ntu.edu.tw/handle/123456789/624484
標題: | Efficacy and safety of combined targeted therapy and immunotherapy versus targeted monotherapy in unresectable hepatocellular carcinoma: a systematic review and meta-analysis | 作者: | Yang, Teng-Kai Yu, Ya-Fang CHIAO-LING TSAI Li, Hsing-Ju Yang, Po-Sheng KAI-WEN HUANG CHIA-HSIEN CHENG |
關鍵字: | Immunotherapy; Meta-analysis; Systematic review; Targeted therapy; Unresectable hepatocellular carcinoma | 公開日期: | 21-十月-2022 | 出版社: | BMC | 卷: | 22 | 期: | 1 | 來源出版物: | BMC cancer | 摘要: | Cancer therapy has evolved from non-specific cytotoxic agents to a selective, mechanism-based approach that includes targeted agents and immunotherapy. Although the response to targeted therapies for unresectable hepatocellular carcinoma (HCC) is acceptable with the improved survival, the high tumor recurrence rate and drug-related side effects continue to be problematic. Given that immune checkpoint inhibitor alone are not robust enough to improve survival in unresectable HCC, growing evidence supports the combination of targeted therapy and immunotherapy with synergistic effect. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/624484 | ISSN: | 1471-2407 | DOI: | 10.1186/s12885-022-10174-6 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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