https://scholars.lib.ntu.edu.tw/handle/123456789/625101
標題: | Enhanced biomedical applicability of ZrO2–SiO2 ceramic composites in 3D printed bone scaffolds | 作者: | CHIH-HAO CHANG Lin, Chih-Yang Chang, Chih-Hung Liu, Fwu-Hsing Huang, Yu-Tzu Liao, Yunn-Shiuan |
公開日期: | 2022 | 卷: | 12 | 期: | 1 | 來源出版物: | Scientific Reports | 摘要: | Zirconia (ZrO2) has been widely used in clinical applications, such as bone and dental implantation, because of its favorable mechanical properties and resistance to fracture. However, the poor cell affinity of ZrO2 for bone regeneration and tissue binding, as well as its shrinkage due to crystal phase transformation during heat treatment, limits its clinical use and processing plasticity. This study aims to investigate an appropriate ZrO2–SiO2 composite recipe for ceramic 3D printing processes that can strike a balance between the mechanical properties and cell affinity needed in clinical applications. Specimens with different ZrO2–SiO2 composite recipes were fabricated by a selective laser gelling method and sintered at temperatures ranging from 900 to 1500 °C. The S5Z5 composite, which consists of 50 wt% ZrO2, 35 wt% SiO2 and 15 wt% SiO2 sol, showed an appropriate compressive strength and bending strength of 82.56 MPa and 55.98 MPa, respectively, at a sintering temperature of 1300 °C. The shrinkage rate of the S5Z5 composite was approximately 5% when the sintering temperature was increased from 900 to 1500 °C. All composites exhibited no cytotoxicity after 144 h of MG63 cell incubation, and the S5Z5 composite exhibited the most obvious cell affinity among the composite recipes. From these results, compared with other composites, the S5Z5 composite was shown to possess mechanical properties and a cell affinity more comparable to those of natural human bone. © 2022, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128925039&doi=10.1038%2fs41598-022-10731-w&partnerID=40&md5=d37d0ea893886b3977a43811593d5583 https://scholars.lib.ntu.edu.tw/handle/123456789/625101 |
ISSN: | 20452322 | DOI: | 10.1038/s41598-022-10731-w | SDG/關鍵字: | silicon dioxide; bone; bone regeneration; ceramics; chemistry; human; three dimensional printing; Bone and Bones; Bone Regeneration; Ceramics; Humans; Printing, Three-Dimensional; Silicon Dioxide |
顯示於: | 機械工程學系 |
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