https://scholars.lib.ntu.edu.tw/handle/123456789/625309
標題: | The synergistic effect of chemo-photothermal therapies in SN-38-loaded gold-nanoshell-based colorectal cancer treatment | 作者: | Yang S.-J Huang H.-T Huang C.-H Pai J.-A Wang C.-H MING-JIUM SHIEH |
關鍵字: | 7-ethyl-10-hydroxycamptothecin; chemotherapy; colorectal cancer; gold nanoshell; human serum albumin; multifunctional therapy; near-infrared laser; photothermal therapy; polyethylenimine | 公開日期: | 2022 | 卷: | 17 | 期: | 1 | 起(迄)頁: | 23-40 | 來源出版物: | Nanomedicine | 摘要: | Aim: 7-Ethyl-10-hydroxycamptothecin (SN-38)-loaded gold nanoshells nanoparticles (HSP@Au NPs) were developed for combined chemo-photothermal therapy to treat colorectal cancer. Materials & methods: SN-38-loaded nanoparticles (HSP NPs) were prepared by the lyophilization-hydration method, and then developed into gold nanoshells. The nanoparticles were characterized and assessed for photothermal properties, cytotoxicity and hemocompatibility in vitro. In vivo anticancer activity was tested in a tumor mouse model. Results: The HSP@Au NPs (diameter 186.9 nm, zeta potential 33.4 mV) led to significant cytotoxicity in cancer cells exposed to a near-infrared laser. Moreover, the HSP@Au NP-mediated chemo-photothermal therapy displayed significant tumor growth suppression and disappearance (25% of tumor clearance rate) without adverse side effects in vivo. Conclusion: HSP@Au NPs may be promising in the treatment of colorectal cancer in the future. © 2021 Future Medicine Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122486977&doi=10.2217%2fnnm-2021-0187&partnerID=40&md5=df2556513deba15b401f6794b5d38a5b https://scholars.lib.ntu.edu.tw/handle/123456789/625309 |
ISSN: | 17435889 | DOI: | 10.2217/nnm-2021-0187 | SDG/關鍵字: | doxorubicin; irinotecan; nanoshell; animal; colorectal tumor; mouse; phototherapy; photothermal therapy; tumor cell line; Animals; Cell Line, Tumor; Colorectal Neoplasms; Doxorubicin; Irinotecan; Mice; Nanoshells; Phototherapy; Photothermal Therapy |
顯示於: | 醫學工程學研究所 |
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