https://scholars.lib.ntu.edu.tw/handle/123456789/625636
標題: | Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivores | 作者: | Hung C.-J PO-CHAO HUANG SHAO-CHUN LU Li Y.-H Huang H.-B BI-FONG LIN Chang S.-J Chou H.-F. |
關鍵字: | Folate; Homocysteine; Humans; Vegetarian diet; Vitamin B-12 | 公開日期: | 2002 | 卷: | 132 | 期: | 2 | 起(迄)頁: | 152-158 | 來源出版物: | Journal of Nutrition | 摘要: | Mild hyperhomocysteinemia is an independent risk factor for cardiovascular disease and may result from a deficiency of folate, vitamin B-6 or vitamin B-12. Because vitamin B-12 deficiency is often associated with vegetarianism, this study was designed to examine the effect of Taiwanese vegetarian diets on B-vitamin status and plasma homocysteine levels. Female Buddhist lacto-vegetarians (n = 45; 31-45 y) and matched omnivores (n = 45) recruited in Hualien, Taiwan, were investigated. Taiwanese vegetarians consumed normal amount of folate, but only 21% of Taiwan Recommended Daily Nutrient Allowances (RDNA) values of vitamin B-12. Compared with the omnivores, the vegetarians had significantly higher levels of plasma folate (14.79 ± 7.70 vs, 11.98 ± 8.29 nmol/L), but lower levels of vitamin B-12 (207.7 ± 127.1 vs. 403.5 ± 138.9 pmol/L). Fasting plasma homocysteine levels were significantly higher in vegetarians than in omnivores (mean: 11.20 ± 4.27 vs. 8.64 ± 2.06 μmol/L; median: 10.5 vs. 8.5 μmol/L). Fasting plasma homocysteine was inversely correlated with plasma folate and vitamin B-12 in the vegetarian group. Multiple regression analysis revealed that plasma folate, vitamin B-12 and creatinine were independent determinants of homocysteine variation and contributed to 38.6% of homocysteine variation in the vegetarians. Compared with the omnivores, vegetarians also had significantly lower serum levels of valine, isoleucine, leucine, lysine, alanine and arginine, but higher levels of glycine. In the vegetarian group, fasting plasma homocysteine correlated negatively with serum threonine, lysine, histidine, arginine and cystine, and these amino acids contributed to 38.7% of homocysteine variation. In conclusion, the Buddhist nuns who consumed a lacto-vegetarian diet had mildly elevated fasting plasma homocysteine levels presumably due to lower levels of plasma vitamin B-12. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036168269&doi=10.1093%2fjn%2f132.2.152&partnerID=40&md5=aa9aace25e038daf36af42efee95e3c9 https://scholars.lib.ntu.edu.tw/handle/123456789/625636 |
ISSN: | 00223166 | DOI: | 10.1093/jn/132.2.152 | SDG/關鍵字: | arginine; cyanocobalamin; cysteine; folic acid; glycine; histidine; homocysteine; lysine; pyridoxine; threonine; amino acid blood level; article; cardiovascular risk; folic acid deficiency; human; hyperhomocysteinemia; multiple regression; nonhuman; risk factor; Taiwan; vegetarian diet; vitamin blood level |
顯示於: | 生化科技學系 |
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