https://scholars.lib.ntu.edu.tw/handle/123456789/626045
標題: | Effectiveness of bacillus licheniformis-fermented products and their derived antimicrobial lipopeptides in controlling coccidiosis in broilers | 作者: | Yu Y.-H Wu C.-M Chen W.-J Hua K.-F JE-RUEI LIU Cheng Y.-H. |
關鍵字: | Antimicrobial lipopeptide; Bacillus licheniformis; Broiler; Coccidiosis; Surfactin | 公開日期: | 2021 | 卷: | 11 | 期: | 12 | 來源出版物: | Animals | 摘要: | This study aimed to investigate the potential of Bacillus licheniformis-fermented products (BLFP) and their derived antimicrobial lipopeptide, surfactin, for the prevention of coccidiosis in broilers. Broilers were fed BLFP at 1.25 and 5 g/kg under Eimeria tenella challenge. At the end of experiment (35 days), the growth performance, survival rate, cecal morphology, cecal lesion scores, oocyst-count index, and anti-coccidial index were analyzed. The effects of the BLFP-derived surfactin on oocyst sporulation and sporozoite morphology in Eimeria species were also investigated in vitro. Results showed that BLFP supplementation at 1.25 and 5 g/kg improved cecal morphology and increased the survival rate of broilers under E. tenella challenge. Supplementation with 1.25 g/kg of BLFP reduced the lesion scores in the cecum of E. tenella-challenged broilers, while the oocyst-count index was reduced in broilers given 5 g/kg of BLFP. The anti-coccidial index of the 1.25 g/kg of BLFP-treated group was greater than 160, compared with the E. tenella-challenge-only group. Furthermore, surfactin inhibited Eimeria oocyst sporulation and disrupted sporozoite morphology. These results demonstrate that BLFPs and their derived antimicrobial lipopeptide, surfactin, exhibit anti-coccidial activity in vitro and in vivo. BLFP may be used as a natural feed additive for the prevention of coccidiosis in broilers, and 1.25 g/kg can be considered the optimum dosage. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121118231&doi=10.3390%2fani11123576&partnerID=40&md5=11815ba4ca28312c491b76ef88d04198 https://scholars.lib.ntu.edu.tw/handle/123456789/626045 |
ISSN: | 20762615 | DOI: | 10.3390/ani11123576 | SDG/關鍵字: | alcohol; alpha tocopherol; coccidiostatic agent; folic acid; food additive; lipopeptide; pyridoxine; selenium; silicon dioxide; surfactin; taurodeoxycholic acid; trace element; trypsin; animal experiment; animal model; antimicrobial activity; Article; Bacillus licheniformis; bacterium contamination; body weight; coccidiosis; diet supplementation; DNA extraction; fermented product; food intake; intestine flora; microscopy; nonhuman; oocyst; sporocyst; sporogenesis; survival rate |
顯示於: | 生物科技研究所 |
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