https://scholars.lib.ntu.edu.tw/handle/123456789/626166
標題: | The antimicrobial activity of heyneanol A extracted from the root of taiwanese wild grape | 作者: | Peng S.-C Cheng C.-Y FUU SHEU Su C.-H. |
關鍵字: | Antimicrobial activity; Grape root; Heyneanol A; Methicillin-resistant Staphylococcus aureus (MRSA); Vitis rotundifolia; Vitis thunbergii | 公開日期: | 2008 | 卷: | 105 | 期: | 2 | 起(迄)頁: | 485-491 | 來源出版物: | Journal of Applied Microbiology | 摘要: | Aims: To search for antimicrobial compounds against pathogenic bacteria from grape vines (Vitis spp.). To investigate the antimicrobial efficacy of active compounds towards methicillin-resistant Staphylococcus aureus (MRSA). Methods and Results: The root extracts of taiwanese wild grape (Vitis thunbergii var. taiwaniana) showed marked activities against Gram-positive bacteria using the disc diffusion method. After purification, the active compound 1 was confirmed as heyneanol A by mass spectroscopy and nuclear magnetic resonance. Heyneanol A showed an minimum inhibitory concentration (MIC) value of 2 μg ml-1 towards MRSA and a value of 2 to 4 μg ml-1 for Enterococcus faecium, S. aureus, Streptococcus agalactiae and Streptococcus pyogenes. In addition, the contents of heyneanol A were determined as 36 mg g-1 in roots of taiwanese wild grape. Conclusions: The root extracts of grapevines have good antimicrobial activities towards some strains of Gram-positive pathogens. Heyneanol A, the major antimicrobial compound, is especially active towards MRSA. In addition, the abundances of heyneanol A and other stilbenes in the roots of grapevines make it possible to produce natural antimicrobial compounds from this plant species. Significance and Impact of the Study: This study reports for the first time the antimicrobial compounds in the root extracts of grapevines. The results will have clinical significance owing to their activities against MRSA. © 2008 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-47249160253&doi=10.1111%2fj.1365-2672.2008.03766.x&partnerID=40&md5=3e9b2e9eb255aa920a3349ea87d10c79 https://scholars.lib.ntu.edu.tw/handle/123456789/626166 |
ISSN: | 13645072 | DOI: | 10.1111/j.1365-2672.2008.03766.x | SDG/關鍵字: | heyneanol a; plant extract; antibiotic resistance; antimicrobial activity; bacterium; inhibitor; mass spectrometry; pathogen; polymer; root system; vine; wild population; antibacterial activity; article; bacterial strain; controlled study; disk diffusion; drug determination; drug efficacy; drug isolation; drug purification; Enterococcus faecium; grape; mass spectrometry; methicillin resistant Staphylococcus aureus; minimum inhibitory concentration; nonhuman; nuclear magnetic resonance imaging; plant root; Streptococcus agalactiae; Streptococcus pyogenes; Taiwan; vitis taiwaniana; wild type; Anti-Bacterial Agents; Enterococcus faecium; Methicillin Resistance; Microbial Sensitivity Tests; Plant Extracts; Plant Roots; Staphylococcus aureus; Stilbenes; Streptococcus agalactiae; Streptococcus pyogenes; Taiwan; Vitis; Enterococcus faecium; methicillin resistant Staphylococcus aureus; Posibacteria; Staphylococcus aureus; Streptococcus agalactiae; Streptococcus pyogenes; Vitaceae; Vitis; Vitis rotundifolia; Vitis sinocinerea; Vitis thunbergii |
顯示於: | 園藝暨景觀學系 |
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