https://scholars.lib.ntu.edu.tw/handle/123456789/626395
標題: | Current opinion on use of luteinizing hormone supplementation in assisted reproduction therapy: an Asian perspective | 作者: | Wong, Peng Cheang Qiao, Jie Ho, Clement Ramaraju, Gottumukkala A Wiweko, Budi Takehara, Yuji Nadkarni, Prashant V Cheng, Li-Chang HSIN-FU CHEN Suwajanakorn, Somchai Vuong, Thi Ngoc Lan |
關鍵字: | Asia; GnRH agonist; IVF; ovarian stimulation; recombinant LH; FOLLICLE-STIMULATING-HORMONE; IN-VITRO FERTILIZATION; RECOMBINANT HUMAN LH; CONTROLLED OVARIAN HYPERSTIMULATION; AGONIST DOWN-REGULATION; NORMOGONADOTROPHIC WOMEN; SUBOPTIMAL RESPONSE; ANOVULATORY WOMEN; LONG PROTOCOL; LIVE BIRTH | 公開日期: | 七月-2011 | 出版社: | ELSEVIER SCI LTD | 卷: | 23 | 期: | 1 | 起(迄)頁: | 81 | 來源出版物: | Reproductive biomedicine online | 摘要: | LH and FSH have complementary functions in ensuring optimal oocyte maturation and ovulation. In women undergoing assisted reproduction technology protocols with gonadotrophin-releasing hormone analogues, LH and FSH concentrations are reduced. While FSH use in assisted reproduction technology is well established, there is no published consensus on the need for exogenous LH in Asian patients. Having reviewed the concept of the LH therapeutic window and differences between recombinant human LH (r-HLH) and human menopausal gonadotrophin, a consensus was reached on which patient subgroups may benefit from LH supplementation. Adjuvant r-HLH gives clinicians precise control over the dose of LH bioactivity administered to target the therapeutic window. The use of r-HLH is recommended in women with poor response in a previous cycle or suboptimal follicular progression in a current cycle by day 6-8 of stimulation. r-HLH should also be considered in women at risk of suboptimal response, specifically age > 35 years. Other risk markers that suggest the need for LH supplementation, which include baseline/day-6 serum LH and anti-Müllerian hormone concentrations, antral follicle count and LH polymorphisms require further research and verification. For measurement of LH response adequacy, the monitoring of follicular progression, oestradiol concentrations and endometrial thickness is recommended. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626395 | ISSN: | 1472-6483 | DOI: | 10.1016/j.rbmo.2011.03.023 |
顯示於: | 醫學系 |
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