https://scholars.lib.ntu.edu.tw/handle/123456789/626435| Title: | H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline, in senescent human fetal mesenchymal stem cells | Authors: | Ho, Pai-Jiun MEN-LUH YEN Tang, Bo-Chung Chen, Chiung-Tong Yen, B Linju |
Keywords: | PROTEIN-KINASE-C; CELLULAR SENESCENCE; MULTIPOTENT CELLS; ROS PRODUCTION; STROMAL CELLS; BONE-MARROW; EPITHELIAL-CELLS; IN-VITRO; AGE; SIRT1 | Issue Date: | 20-May-2013 | Publisher: | MARY ANN LIEBERT, INC | Journal Volume: | 18 | Journal Issue: | 15 | Start page/Pages: | 1895 | Source: | Antioxidants & redox signaling | Abstract: | Mesenchymal stem cells (MSCs) with multilineage differentiation capacity and immunomodulatory properties are novel sources for cell therapy. However, in vitro expansion of these rare somatic stem cells leads to senescence, resulting in declines of differentiation and proliferative capacities. We therefore investigated the mechanisms mediating senescence in human fetal MSCs termed placenta-derived multipotent cells (PDMCs). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626435 | ISSN: | 1523-0864 1557-7716 |
DOI: | 10.1089/ars.2012.4692 |
| Appears in Collections: | 醫學系 |
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