https://scholars.lib.ntu.edu.tw/handle/123456789/626472
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu, Ho-Cheng | en_US |
dc.contributor.author | Chen, Yu-Chang | en_US |
dc.contributor.author | Hsieh, Chin-Lin | en_US |
dc.contributor.author | Hsiao, George | en_US |
dc.contributor.author | Wang, Shih-Wei | en_US |
dc.contributor.author | Cheng, Ming-Jen | en_US |
dc.contributor.author | Chao, Che-Yi | en_US |
dc.contributor.author | TZONG-HUEI LEE | en_US |
dc.contributor.author | Kuo, Yueh-Hsiung | en_US |
dc.date.accessioned | 2022-12-15T03:51:27Z | - |
dc.date.available | 2022-12-15T03:51:27Z | - |
dc.date.issued | 2022-08-24 | - |
dc.identifier.issn | 0031-9422 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/626472 | - |
dc.description.abstract | One undescribed C40 terpenoid, calomacroquinoic acid; four undescribed diterpenes, 5α,6α-epoxy-7α-hydroxyferruginol, 15-ethoxysugiol, 7-methoxy-6,7-secoabieta-8,11,13-triene-6,12-diol, and ethyl 7,8-secoabieta-11,14-dioxo-7-ate; two compounds isolated from Nature for the first time, 6β,7α-dihydroxyferruginol and 12-O-methyltaxochinon; and six known compounds were successfully identified from the bark of Taiwan incense cedar Calocedrus formosana. Structures of all isolates were elucidated by physical data (appearance, ultraviolet, infrared, specific rotation, and X-ray) and spectroscopic data (1D and 2D nuclear magnetic resonance, and high-resolution electron ionization mass spectrometry). The biosynthetic pathway of calomacroquinoic acid is also described in the current study. Nitric oxide production in lipopolysaccharide (LPS)-stimulated BV-2 microglia cells was inhibited by 6,7-dehydroferruginol, 7α,11-dihydroxy-12-methoxy-8,11,13-abietriene, and trans-communic acid. Altogether, the bark of C. formosana possessed several potential natural therapeutics against inflammation-related neuronal diseases. | en_US |
dc.language.iso | en | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.relation.ispartof | Phytochemistry | en_US |
dc.subject | Anti-inflammatory activity; BV-2 microglial cells; Calocedrus formosana; Cupressaceae; Diterpenes; Taiwan incense cedar; Tetraterpene | en_US |
dc.title | Chemical constituents and their anti-neuroinflammatory activities from the bark of Taiwan incense cedar, Calocedrus formosana | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.phytochem.2022.113347 | - |
dc.identifier.pmid | 36027968 | - |
dc.identifier.scopus | 2-s2.0-85138541739 | - |
dc.identifier.isi | WOS:000861808800006 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85138541739 | - |
dc.relation.journalvolume | 204 | en_US |
dc.relation.journalissue | 113347 | en_US |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Fisheries Science | - |
crisitem.author.dept | Life Science | - |
crisitem.author.orcid | 0000-0001-8036-7563 | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
顯示於: | 漁業科學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。