https://scholars.lib.ntu.edu.tw/handle/123456789/626473
標題: | Anti-Epstein-Barr Viral Agents from the Medicinal Herb-Derived Fungus Alternaria alstroemeriae Km2286 | 作者: | Chang, Chia-Hao Lee, Yi-Chieh Hsiao, George Chang, Li-Kwan Chi, Wei-Chiung Cheng, Yuan-Chung Huang, Shu-Jung Wang, Tai-Chou Lu, Yi-Shan TZONG-HUEI LEE |
關鍵字: | VIRUS LYTIC CYCLE; TENUAZONIC ACID; 3-MERCAPTOLACTATE; PERYLENEQUINONE; INHIBITION; PEPTIDES | 公開日期: | 25-十一月-2022 | 出版社: | AMER CHEMICAL SOC | 卷: | 85 | 期: | 11 | 起(迄)頁: | 2667-2674 | 來源出版物: | Journal of natural products | 摘要: | Chromatographic separation on the liquid-state fermented products produced by the fungal strain Alternaria alstroemeriae Km2286 isolated from the littoral medicinal herb Atriplex maximowicziana Makino resulted in the isolation of compounds 1-9. Structures were determined by spectroscopic analysis as four undescribed perylenequinones, altertromins A-D (1-4), along with altertoxin IV (5), altertoxin VIII (6), stemphyperylenol (7), tenuazonic acid (8), and allo-tenuazonic acid (9). Compounds 1-6 exhibited antiviral activities against Epstein-Barr virus (EBV) with EC50 values ranging from 0.17 ± 0.07 to 3.13 ± 0.31 μM and selectivity indices higher than 10. In an anti-neuroinflammatory assay, compounds 1-4, 6, and 7 showed inhibitory activity of nitric oxide production in lipopolysaccharide-induced microglial BV-2 cells, with IC50 values ranging from 0.33 ± 0.04 to 4.08 ± 0.53 μM without significant cytotoxicity. This is the first report to describe perylenequinone-type compounds with potent anti-EBV and anti-neuroinflammatory activities. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626473 | ISSN: | 0163-3864 | DOI: | 10.1021/acs.jnatprod.2c00783 |
顯示於: | 漁業科學研究所 |
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