https://scholars.lib.ntu.edu.tw/handle/123456789/626703
標題: | Pd-Promoted Cyclization of (Z)-Pent-2-en-4-yn-1-yl Alkanoates Leading to Furans via an Acyl Group Shift and Further Synthetic Transformation | 作者: | Chiang, Ai-Chun Liu, Yi-Hung SHIE-MING PENG SHIUH-TZUNG LIU |
關鍵字: | CLEAVAGE | 公開日期: | 21-十月-2022 | 出版社: | AMER CHEMICAL SOC | 卷: | 24 | 期: | 41 | 起(迄)頁: | 7649 | 來源出版物: | Organic letters | 摘要: | Palladium-promoted acyl migration was observed in the reaction of (Z)-pent-2-en-4-yn-1-yl alkanoates in the presence of DBU to yield 2-(alkanoylmethyl)furan derivatives (2) in high yields. Compounds 2 then underwent oxidative decarbonylation to afford 2-acylfurans with O2 as the oxidant under mild and metal-free conditions. The mechanistic pathway of the reaction involving an intramolecular cyclization and acyl group shift is discussed. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626703 | ISSN: | 1523-7060 | DOI: | 10.1021/acs.orglett.2c03147 |
顯示於: | 化學系 |
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