https://scholars.lib.ntu.edu.tw/handle/123456789/626712
標題: | Propensity score matching analysis comparing radical prostatectomy and radiotherapy with androgen deprivation therapy in locally advanced prostate cancer | 作者: | Lu, Yu-Cheng CHAO-YUAN HUANG CHIA-HSIEN CHENG KUO-HOW HUANG YU-CHUAN LU PO-MING CHOW YI-KAI CHANG YEONG-SHIAU PU CHUNG-HSIN CHEN SHAO-LUN LU KENG-HSUEH LAN FU-SHAN JAW Chen, Pei-Ling JIAN-HUA HONG |
關鍵字: | UROLOGICAL RESEARCH; SURVIVAL; TRIAL | 公開日期: | 21-七月-2022 | 出版社: | NATURE PORTFOLIO | 卷: | 12 | 期: | 1 | 來源出版物: | Scientific reports | 摘要: | To compare clinical outcomes between the use of robotic-assisted laparoscopic radical prostatectomy (RP) and radiotherapy (RT) with long-term androgen deprivation therapy (ADT) in locally advanced prostate cancer (PC), 315 patients with locally advanced PC (clinical T-stage 3/4) were considered for analysis retrospectively. Propensity score-matching at a 1:1 ratio was performed. The median follow-up period was 59.2 months (IQR 39.8-87.4). There were 117 (37.1%) patients in the RP group and 198 (62.9%) patients in the RT group. RT patients were older and had higher PSA at diagnosis, higher Gleason score grade group and more advanced T-stage (all p < 0.001). After propensity score-matching, there were 68 patients in each group. Among locally advanced PC patients, treatment with RP had a higher risk of biochemical recurrence compared to the RT group. In multivariate Cox regression analysis, treatment with RT plus ADT significantly decreased the risk of biochemical failure (HR 0.162, p < 0.001), but there was no significant difference in local recurrence, distant metastasis and overall survival (p = 0.470, p = 0.268 and p = 0.509, respectively). This information supported a clinical benefit in BCR control for patients undergoing RT plus long-term ADT compared to RP. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626712 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-022-16700-7 |
顯示於: | 醫學系 |
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