https://scholars.lib.ntu.edu.tw/handle/123456789/626805
標題: | RTL1/PEG11 imprinted in human and mouse brain mediates anxiety-like and social behaviors and regulates neuronal excitability in the locus coeruleus | 作者: | MING-YI CHOU Hu, Meng-Chuen Chen, Pin-Yu Hsu, Chi-Lin Lin, Ting-Yu Tan, Mao-Jia Lee, Chih-Yu MENG-FAI KUO PEI-HSIN HUANG VIN-CENT WU SHIH-HUNG YANG PI-CHUAN FAN Huang, Hsin-Yi Akbarian, Schahram Loo, Tsui-Han Stewart, Colin L HSIANG-PO HUANG SUSAN SHUR-FEN GAU HSIEN-SUNG HUANG |
關鍵字: | AMYGDALA; MAZE; RTL1 | 公開日期: | 10-九月-2022 | 出版社: | OXFORD UNIV PRESS | 卷: | 31 | 期: | 18 | 起(迄)頁: | 3161 | 來源出版物: | Human molecular genetics | 摘要: | RTL1/PEG11, which has been associated with anxiety disorders, is a retrotransposon-derived imprinted gene in the placenta. However, imprinting patterns and functions of RTL1 in the brain have not been well-investigated. We found Rtl1 was paternally, but not maternally, expressed in brain stem, thalamus, and hypothalamus of mice, and imprinting status of RTL1 was maintained in human brain. Paternal Rtl1 knockout (Rtl1m+/p-) mice had higher neonatal death rates due to impaired suckling, and low body weights beginning on embryonic day 16.5. High paternal expression of Rtl1 was detected in the locus coeruleus (LC) and Rtl1m+/p- mice showed an increased delay in time of onset for action potentials and inward currents with decreased neuronal excitability of LC neurons. Importantly, Rtl1m+/p- mice exhibited behaviors associated with anxiety, depression, fear-related learning and memory, social dominance, and low locomotor activity. Taken together, our findings demonstrate RTL1 is imprinted in brain, mediates emotional and social behaviors, and regulates excitability in LC neurons. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/626805 | ISSN: | 0964-6906 | DOI: | 10.1093/hmg/ddac110 |
顯示於: | 醫學系 |
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